International study on low-grade primary central nervous system lymphoma

Kristoph Jahnke, Agnieszka Korfei, Brian Patrick O'Neill, Jean Yves Blay, Lauren E. Abrey, Peter Martus, Philip M P Poortmans, Tamara N. Shenkier, Tracy T. Batchelor, Edward A. Neuwelt, Jeffrey J. Raizer, David Schiff, Hendrik Pels, Ulrich Herrlinger, Harald Stein, Eckhard Thiel

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: The aim of this study was to characterize the clinical presentation, course, and outcome of low-grade primary central nervous system lymphoma. Methods: Cases were assessed in a retrospective series collected from 18 cancer centers in 5 countries. Results: Forty patients (18 men, 22 women; median age, 60 years [range, 19-78]) were identified. Involvement of a cerebral hemisphere or deeper brain structures was seen in 37 patients, only leptomeningeal involvement in 2 patients, and spinal cord disease in 1 patient. Chemotherapy/radiotherapy was conducted in 15 patients, radiotherapy alone in 12, chemotherapy alone in 10, and tumor resection alone in 2, whereas 1 patient received no treatment. The median progression-free, disease-specific, and overall survival were 61.5 (range, 0-204), 130 (range, 1-204), and 79 (range, 1-204) months, respectively. Only age 60 years or older was associated with shorter progression-free (p = 0.009), disease-specific (p = 0.015), and overall survival (p = 0.001) in multivariate analysis. Interpretation: Low-grade primary central nervous system lymphoma differs from the high-grade subtype in its pathological, clinical, and radiological features. It has a better long-term outcome than primary central nervous system lymphoma in general with age 60 years or older adversely affecting survival.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
JournalAnnals of Neurology
Volume59
Issue number5
DOIs
StatePublished - May 2006

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Lymphoma
Central Nervous System
Survival
Radiotherapy
Drug Therapy
Spinal Cord Diseases
Cerebrum
Non-Hodgkin's Lymphoma
Disease Progression
Neoplasms
Multivariate Analysis
Brain
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jahnke, K., Korfei, A., O'Neill, B. P., Blay, J. Y., Abrey, L. E., Martus, P., ... Thiel, E. (2006). International study on low-grade primary central nervous system lymphoma. Annals of Neurology, 59(5), 755-762. https://doi.org/10.1002/ana.20804

International study on low-grade primary central nervous system lymphoma. / Jahnke, Kristoph; Korfei, Agnieszka; O'Neill, Brian Patrick; Blay, Jean Yves; Abrey, Lauren E.; Martus, Peter; Poortmans, Philip M P; Shenkier, Tamara N.; Batchelor, Tracy T.; Neuwelt, Edward A.; Raizer, Jeffrey J.; Schiff, David; Pels, Hendrik; Herrlinger, Ulrich; Stein, Harald; Thiel, Eckhard.

In: Annals of Neurology, Vol. 59, No. 5, 05.2006, p. 755-762.

Research output: Contribution to journalArticle

Jahnke, K, Korfei, A, O'Neill, BP, Blay, JY, Abrey, LE, Martus, P, Poortmans, PMP, Shenkier, TN, Batchelor, TT, Neuwelt, EA, Raizer, JJ, Schiff, D, Pels, H, Herrlinger, U, Stein, H & Thiel, E 2006, 'International study on low-grade primary central nervous system lymphoma', Annals of Neurology, vol. 59, no. 5, pp. 755-762. https://doi.org/10.1002/ana.20804
Jahnke, Kristoph ; Korfei, Agnieszka ; O'Neill, Brian Patrick ; Blay, Jean Yves ; Abrey, Lauren E. ; Martus, Peter ; Poortmans, Philip M P ; Shenkier, Tamara N. ; Batchelor, Tracy T. ; Neuwelt, Edward A. ; Raizer, Jeffrey J. ; Schiff, David ; Pels, Hendrik ; Herrlinger, Ulrich ; Stein, Harald ; Thiel, Eckhard. / International study on low-grade primary central nervous system lymphoma. In: Annals of Neurology. 2006 ; Vol. 59, No. 5. pp. 755-762.
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