International Council for Standardization in Haematology (ICSH) recommendations for "Surrogate Reference" method for the packed cell volume

B. S. Bull, K. Fujimoto, B. Houwen, G. Klee, L. van Hove, O. W. van Assendelft, A. Bunyaratvej, M. Buttarello, B. Davis, J. A. Koepke, S. M. Lewis, S. J. Machin, G. d'Onofrio, R. M. Rowan, N. Tatsumi

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The spun packed cell volume (PCV, hematocrit) is a key measurement on which are based hematology instrument calibration, reference range determination, and assignment of values to calibrators/controls. In 2001, the International Council for Standardization in Haematology (ICSH) recommended a Reference PCV method, which is fully traceable to the ICSH reference hemoglobin method. Because of its complexity, however, this method is impractical for occasional use in routine laboratories and is therefore intended primarily for use by manufacturers of capillary microhematocrit tubes, liquid calibrators, and multi-channel analyzers. In response to the need for a simpler method - accessible to all routine laboratories - the ICSH offers this "Surrogate Reference" PCV procedure. It is traceable to the original ICSH Reference PCV method and is based on spun PCVs obtained using borosilicate capillary tubes with an already-known relationship to this reference procedure. This ICSH "Surrogate Reference" PCV method is substantially simpler, thus putting it within the reach of most routine hematology laboratories.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalLaboratory Hematology
Volume9
Issue number1
StatePublished - Apr 16 2003

Keywords

  • Hematocrit
  • Packed cell volume (PCV)
  • Reference method

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical

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