International consensus for the treatment of autoimmune pancreatitis

Kazuichi Okazaki, Suresh T. Chari, Luca Frulloni, Markus M. Lerch, Terumi Kamisawa, Shigeyuki Kawa, Myung Hwan Kim, Philippe Lévy, Atsushi Masamune, George Webster, Tooru Shimosegawa

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Background and aims The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP. Methods By a modified Delphi approach, a panel of international experts has proposed an international consensus on the treatment of AIP after intense discussion and deliberation during an international consensus symposium of the International Association of Pancreatology (IAP) 2016. Results Individual statements for nine clinical questions with recommendation levels and the therapeutic strategy have been proposed. Conclusion The recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide. These recommendations can be tailored according to the local expertise and context in the management of individual patients.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalPancreatology
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Autoimmune pancreatitis
  • Immunomodulatory
  • Rituximab
  • Steroid
  • Treatment

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

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    Okazaki, K., Chari, S. T., Frulloni, L., Lerch, M. M., Kamisawa, T., Kawa, S., Kim, M. H., Lévy, P., Masamune, A., Webster, G., & Shimosegawa, T. (2017). International consensus for the treatment of autoimmune pancreatitis. Pancreatology, 17(1), 1-6. https://doi.org/10.1016/j.pan.2016.12.003