International Analysis of LVAD Point-of-Care Versus Plasma INR: A Multicenter Study

Sarah Schettle, Thomas Schlöglhofer, Daniel Zimpfer, Heinrich Schima, Friedrich Kaufmann, Anthony Salimbangon, Jennifer Wolforth, Sarah Schroeder, Rachel Hards, Brianne Ritchie, Linda Staley, Naveen Luke Pereira, Sudhir Kushwaha, Simon Maltais, John Stulak

Research output: Contribution to journalArticle

Abstract

International normalized ratio (INR) measurements manage risks of bleeding and clotting sequelae in the population with left ventricular assist device (LVAD). Studies suggest that point-of-care (POC) INR does not significantly differ from plasma INR (P-INR) values in other patient populations, although this has not been validated in a multicenter LVAD study. We sought to determine whether POC-INR and P-INR values differ significantly in the LVAD population and reviewed patients with permanent LVAD implantation at seven institutions internationally. Our cohort comprised of 279 paired POC-INR and P-INR checks in patients supported on average 630 ± 598 days postimplant with predominately HeartWare, HeartMate II, and HeartMate III devices. The population averaged 57.9 years of age, and there were 86.7% male. We found no statistically significant difference between POC-INR and P-INR values. International normalized ratio accuracy correlated weakly with the time between INR measurements (p < 0.001). When the time difference was less than 4 hours, the difference between INR pairs was significantly lower than measurements greater than 8 hours (p = 0.006). There was no statistically significant difference when comparing paired INR values and time after implant to INR check (p = 0.43), age (p = 0.12), known coagulopathy (p = 0.12), bleeding history (p = 0.22), or thrombosis history (p = 0.34). This is the first large multicenter international study comparing POC-INR and P-INR measurements in patients with LVAD and found no statistically significant difference between either methods, particularly when measured within less than 4 hours of each other.

Original languageEnglish (US)
Pages (from-to)e161-e165
JournalASAIO journal (American Society for Artificial Internal Organs : 1992)
Volume64
Issue number6
DOIs
StatePublished - Nov 1 2018

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Point-of-Care Systems
Left ventricular assist devices
Heart-Assist Devices
International Normalized Ratio
Multicenter Studies
Plasmas
Population
Hemorrhage

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Schettle, S., Schlöglhofer, T., Zimpfer, D., Schima, H., Kaufmann, F., Salimbangon, A., ... Stulak, J. (2018). International Analysis of LVAD Point-of-Care Versus Plasma INR: A Multicenter Study. ASAIO journal (American Society for Artificial Internal Organs : 1992), 64(6), e161-e165. https://doi.org/10.1097/MAT.0000000000000845

International Analysis of LVAD Point-of-Care Versus Plasma INR : A Multicenter Study. / Schettle, Sarah; Schlöglhofer, Thomas; Zimpfer, Daniel; Schima, Heinrich; Kaufmann, Friedrich; Salimbangon, Anthony; Wolforth, Jennifer; Schroeder, Sarah; Hards, Rachel; Ritchie, Brianne; Staley, Linda; Pereira, Naveen Luke; Kushwaha, Sudhir; Maltais, Simon; Stulak, John.

In: ASAIO journal (American Society for Artificial Internal Organs : 1992), Vol. 64, No. 6, 01.11.2018, p. e161-e165.

Research output: Contribution to journalArticle

Schettle, S, Schlöglhofer, T, Zimpfer, D, Schima, H, Kaufmann, F, Salimbangon, A, Wolforth, J, Schroeder, S, Hards, R, Ritchie, B, Staley, L, Pereira, NL, Kushwaha, S, Maltais, S & Stulak, J 2018, 'International Analysis of LVAD Point-of-Care Versus Plasma INR: A Multicenter Study', ASAIO journal (American Society for Artificial Internal Organs : 1992), vol. 64, no. 6, pp. e161-e165. https://doi.org/10.1097/MAT.0000000000000845
Schettle, Sarah ; Schlöglhofer, Thomas ; Zimpfer, Daniel ; Schima, Heinrich ; Kaufmann, Friedrich ; Salimbangon, Anthony ; Wolforth, Jennifer ; Schroeder, Sarah ; Hards, Rachel ; Ritchie, Brianne ; Staley, Linda ; Pereira, Naveen Luke ; Kushwaha, Sudhir ; Maltais, Simon ; Stulak, John. / International Analysis of LVAD Point-of-Care Versus Plasma INR : A Multicenter Study. In: ASAIO journal (American Society for Artificial Internal Organs : 1992). 2018 ; Vol. 64, No. 6. pp. e161-e165.
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