Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

James J. Lee, Michael P. McGarry, Steven C. Farmer, Karen L. Denzler, Kirsten A. Larson, Patricia E. Carrigan, Ina E. Brenneise, Margaret A. Horton, Angela Haczku, Erwin W. Gelfand, George D. Leikauf, Nancy A. Lee

Research output: Contribution to journalArticle

448 Scopus citations

Abstract

We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation of peribronchial eosinophils and striking pathologic changes including the expansion of bronchus associated lymphoid tissue (BALT), goblet cell hyperplasia, epithelial hypertrophy, and focal collagen deposition. These changes were also accompanied by eosinophil infiltration of the airway lumen. In addition, transgenic animals displayed airway hyperresponsiveness to methacholine in the absence of aerosolized antigen challenge. These findings demonstrate that lung-specific IL-5 expression can induce pathologic changes characteristic of asthma and may provide useful models to evaluate the efficacy of potential respiratory disease therapies or pharmaceuticals.

Original languageEnglish (US)
Pages (from-to)2143-2156
Number of pages14
JournalJournal of Experimental Medicine
Volume185
Issue number12
DOIs
StatePublished - Jun 16 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D., & Lee, N. A. (1997). Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. Journal of Experimental Medicine, 185(12), 2143-2156. https://doi.org/10.1084/jem.185.12.2143