Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease

Liana Fidani; Antonis Goulas; Vassiliki Mirtsou; Ronald C. Petersen; Eric Tangalos; Richard Crook; John Hardy

doi:10.1016/S0304-3940(02)00114-3

Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease

Liana Fidani, Antonis Goulas, Vassiliki Mirtsou, Ronald C. Petersen, Eric Tangalos, Richard Crook, John Hardy

Research output: Contribution to journal › Article › peer-review

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Abstract

Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the ε4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	Neuroscience Letters
Volume	323
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00114-3
State	Published - Apr 19 2002

Keywords

Alzheimer's disease
Genetics
Interleukin-1A
Polymorphism

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(02)00114-3

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title = "Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease",

abstract = "Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the ε4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD.",

keywords = "Alzheimer's disease, Genetics, Interleukin-1A, Polymorphism",

author = "Liana Fidani and Antonis Goulas and Vassiliki Mirtsou and Petersen, {Ronald C.} and Eric Tangalos and Richard Crook and John Hardy",

note = "Funding Information: This work was supported by an NIA/NIH Project Grant to J.H. and Alison Goate, an NIH/NIA Alzheimer Disease Research Center Grant (R.C.P.) and by the Mayo Foundation.",

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doi = "10.1016/S0304-3940(02)00114-3",

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AU - Fidani, Liana

AU - Goulas, Antonis

AU - Mirtsou, Vassiliki

AU - Petersen, Ronald C.

AU - Tangalos, Eric

AU - Crook, Richard

AU - Hardy, John

N1 - Funding Information: This work was supported by an NIA/NIH Project Grant to J.H. and Alison Goate, an NIH/NIA Alzheimer Disease Research Center Grant (R.C.P.) and by the Mayo Foundation.

PY - 2002/4/19

Y1 - 2002/4/19

N2 - Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the ε4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD.

AB - Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the ε4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD.

KW - Alzheimer's disease

KW - Genetics

KW - Interleukin-1A

KW - Polymorphism

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Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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