Interferon-γ, in progression to chronic demyelination and neurological deficit following acute EAE

Toufic Renno, Véronique Taupin, Lyne Bourbonnière, Gail Verge, Elise Tran, Roberta De Simone, Michelle Krakowski, Moses Rodriguez, Alan Peterson, Trevor Owens

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

The cytokine interferon-γ (IFNγ) is implicated in the induction of acute CNS inflammation, but it is less clear what role if any IFNγ plays in progression to chronic demyelination and neurological deficit. To address this issue, we have expressed IFNγ in myelinating oligodendrocytes of transgenic mice. MHC I immunostaining and iNOS mRNA were upregulated in their CNS, but such transgenic mice showed no spontaneous CNS inflammation or demyelination, and the incidence, severity, and histopathology of experimental autoimmune encephalomyelitis (EAE) were similar to nontransgenic controls. In contrast to control mice, which remit from EAE with resolution of glial reactivity and leukocytic infiltration, transgenics showed chronic neurological deficits. While activated microglia/macrophages persisted in demyelinating lesions for over 100 days, CD4+ T lymphocytes were no longer present in CNS. IFNγ therefore may play a role in chronic demyelination and long-term disability following the induction of demyelinating disease. Because IFNγ may have neural as well as immune-infiltrating origins, these findings generate a new perspective on its role in the CNS.

Original languageEnglish (US)
Pages (from-to)376-389
Number of pages14
JournalMolecular and Cellular Neurosciences
Volume12
Issue number6
DOIs
StatePublished - Dec 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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    Renno, T., Taupin, V., Bourbonnière, L., Verge, G., Tran, E., De Simone, R., Krakowski, M., Rodriguez, M., Peterson, A., & Owens, T. (1998). Interferon-γ, in progression to chronic demyelination and neurological deficit following acute EAE. Molecular and Cellular Neurosciences, 12(6), 376-389. https://doi.org/10.1006/mcne.1998.0725