Interferon-γ 3 induces progressive nigrostriatal degeneration and basal ganglia calcification

Paramita Chakrabarty, Carolina Ceballos-Diaz, Wen Lang Lin, Amanda Beccard, Karen Jansen-West, Nikolaus R. McFarland, Christopher Janus, Dennis Dickson, Pritam Das, Todd E. Golde

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46 Scopus citations

Abstract

We found that CNS-directed expression of interferon-γ 3 (IFN-γ 3) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ 3 mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.

Original languageEnglish (US)
Pages (from-to)694-696
Number of pages3
JournalNature Neuroscience
Volume14
Issue number6
DOIs
StatePublished - Jun 1 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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    Chakrabarty, P., Ceballos-Diaz, C., Lin, W. L., Beccard, A., Jansen-West, K., McFarland, N. R., Janus, C., Dickson, D., Das, P., & Golde, T. E. (2011). Interferon-γ 3 induces progressive nigrostriatal degeneration and basal ganglia calcification. Nature Neuroscience, 14(6), 694-696. https://doi.org/10.1038/nn.2829