Interdisciplinary education to integrate pathology and epidemiology

Towards molecular and population-level health science

Shuji Ogino, Emily E. King, Andrew H. Beck, Mark E. Sherman, Danny A. Milner, Edward Giovannucci

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

In recent decades, epidemiology, public health, and medical sciences have been increasingly compartmentalized into narrower disciplines. The authors recognize the value of integration of divergent scientific fields in order to create new methods, concepts, paradigms, and knowledge. Herein they describe the recent emergence of molecular pathological epidemiology (MPE), which represents an integration of population and molecular biologic science to gain insights into the etiologies, pathogenesis, evolution, and outcomes of complex multifactorial diseases. Most human diseases, including common cancers (such as breast, lung, prostate, and colorectal cancers, leukemia, and lymphoma) and other chronic diseases (such as diabetes mellitus, cardiovascular diseases, hypertension, autoimmune diseases, psychiatric diseases, and some infectious diseases), are caused by alterations in the genome, epigenome, transcriptome, proteome, metabolome, microbiome, and interactome of all of the above components. In this era of personalized medicine and personalized prevention, we need integrated science (such as MPE) which can decipher diseases at the molecular, genetic, cellular, and population levels simultaneously. The authors believe that convergence and integration of multiple disciplines should be commonplace in research and education. We need to be open-minded and flexible in designing integrated education curricula and training programs for future students, clinicians, practitioners, and investigators.

Original languageEnglish (US)
Pages (from-to)659-667
Number of pages9
JournalAmerican Journal of Epidemiology
Volume176
Issue number8
DOIs
StatePublished - Oct 15 2012

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Molecular Epidemiology
Health Status
Pathology
Education
Population
Precision Medicine
Metabolome
Biological Science Disciplines
Microbiota
Proteome
Transcriptome
Curriculum
Autoimmune Diseases
Communicable Diseases
Psychiatry
Molecular Biology
Colorectal Neoplasms
Lymphoma
Lung Neoplasms
Prostatic Neoplasms

Keywords

  • education, public health professional
  • health care reform
  • individualized medicine
  • interdisciplinary communication
  • molecular epidemiology
  • pathology

ASJC Scopus subject areas

  • Epidemiology

Cite this

Interdisciplinary education to integrate pathology and epidemiology : Towards molecular and population-level health science. / Ogino, Shuji; King, Emily E.; Beck, Andrew H.; Sherman, Mark E.; Milner, Danny A.; Giovannucci, Edward.

In: American Journal of Epidemiology, Vol. 176, No. 8, 15.10.2012, p. 659-667.

Research output: Contribution to journalArticle

Ogino, Shuji ; King, Emily E. ; Beck, Andrew H. ; Sherman, Mark E. ; Milner, Danny A. ; Giovannucci, Edward. / Interdisciplinary education to integrate pathology and epidemiology : Towards molecular and population-level health science. In: American Journal of Epidemiology. 2012 ; Vol. 176, No. 8. pp. 659-667.
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