Interdependent biological systems, multi-functional molecules: The evolving role of tissue factor pathway inhibitor beyond anti-coagulation

Eric W. Holroyd, Robert D. Simari

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Coagulation, innate immunity, angiogenesis, and lipid metabolism represent fundamental and interdependent biological systems. While tissue factor pathway inhibitor (TFPI) is the major physiological inhibitor of TF, its unique structure and endothelial expression allow multi-modal interactions with constituent molecules in each of these systems. We review emerging data describing roles for TFPI beyond simply opposing the action of TF, particularly with regard to the highly basic c-terminus of TFPI, and highlight potentially exciting new areas for future research.

Original languageEnglish (US)
Pages (from-to)S57-S59
JournalThrombosis research
Volume125
Issue numberSUPPL. 1
DOIs
StatePublished - Apr 2010

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Inflammation
  • Lipid metabolism
  • Tissue factor
  • Tissue factor pathway inhibitor

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Interdependent biological systems, multi-functional molecules: The evolving role of tissue factor pathway inhibitor beyond anti-coagulation'. Together they form a unique fingerprint.

Cite this