Interception of cocaine by enzyme or antibody delivered with viral gene transfer: A novel strategy for preventing relapse in recovering drug users

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Recent progress in enzyme engineering has led to versions of human butyrylcholinesterase (BChE) that hydrolyze cocaine efficiently in plasma, reduce concentrations reaching reward neurocircuity in the brain, and weaken behavioral responses to this drug. Along with enzyme advances, increasingly avid anti-cocaine antibodies and potent anti-cocaine vaccines have also been developed. Here we review these developments and consider the potential advantages along with the risks of delivering drug-intercepting proteins via gene transfer approaches to treat cocaine addiction.

Original languageEnglish (US)
Pages (from-to)880-891
Number of pages12
JournalCNS and Neurological Disorders - Drug Targets
Volume10
Issue number8
DOIs
StatePublished - Dec 2011

Keywords

  • Adeno-associated viral vector
  • Butyrylcholinesterase
  • Cocaine hydrolase
  • Cocaine vaccine
  • Gene therapy
  • Helper-dependent viral vector
  • Monoclonal antibody

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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