Interaction of α-synuclein and tau genotypes in Parkinson's disease

Catherine E. Mamah, Timothy G. Lesnick, Sarah J. Lincoln, Kari J. Strain, Mariza De Andrade, James Howard Bower, J. Eric Ahlskog, Walter A Rocca, Matthew J. Farrer, Demetrius M. Maraganore

Research output: Contribution to journalArticle

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Abstract

To determine whether the microtubule-associated protein tau (MAPT) and α-synuclein (SNCA) genes interact to confer Parkinson's disease (PD) susceptibility, we conducted a study of 557 case-control pairs. There was an increased risk of PD for persons with either SNCA 261/261 or MAPT H1/H1 genotypes as compared with persons with neither (odds ratio, 1.96; 95% confidence interval, 1.34-2.86; p = 0.0003). However, the combined effect of the two genotypes was the same as for either of the genotypes alone (separate and equal). These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of α-synuclein protein at low concentrations (dose threshold effect).

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalAnnals of Neurology
Volume57
Issue number3
DOIs
StatePublished - Mar 2005

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Synucleins
Parkinson Disease
Microtubule-Associated Proteins
Genotype
Disease Susceptibility
Case-Control Studies
Odds Ratio
Confidence Intervals
Genes
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mamah, C. E., Lesnick, T. G., Lincoln, S. J., Strain, K. J., De Andrade, M., Bower, J. H., ... Maraganore, D. M. (2005). Interaction of α-synuclein and tau genotypes in Parkinson's disease. Annals of Neurology, 57(3), 439-443. https://doi.org/10.1002/ana.20387

Interaction of α-synuclein and tau genotypes in Parkinson's disease. / Mamah, Catherine E.; Lesnick, Timothy G.; Lincoln, Sarah J.; Strain, Kari J.; De Andrade, Mariza; Bower, James Howard; Ahlskog, J. Eric; Rocca, Walter A; Farrer, Matthew J.; Maraganore, Demetrius M.

In: Annals of Neurology, Vol. 57, No. 3, 03.2005, p. 439-443.

Research output: Contribution to journalArticle

Mamah, CE, Lesnick, TG, Lincoln, SJ, Strain, KJ, De Andrade, M, Bower, JH, Ahlskog, JE, Rocca, WA, Farrer, MJ & Maraganore, DM 2005, 'Interaction of α-synuclein and tau genotypes in Parkinson's disease', Annals of Neurology, vol. 57, no. 3, pp. 439-443. https://doi.org/10.1002/ana.20387
Mamah, Catherine E. ; Lesnick, Timothy G. ; Lincoln, Sarah J. ; Strain, Kari J. ; De Andrade, Mariza ; Bower, James Howard ; Ahlskog, J. Eric ; Rocca, Walter A ; Farrer, Matthew J. ; Maraganore, Demetrius M. / Interaction of α-synuclein and tau genotypes in Parkinson's disease. In: Annals of Neurology. 2005 ; Vol. 57, No. 3. pp. 439-443.
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