Interaction between erbB- receptors and heregulin in breast cancer tumor progression and drug resistance

Ruth Lupu, Marina Cardillo, Lyndsay Harris, Mai Hijazi, Karen Rosenberg

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The type 1 growth factor receptor family is increasingly recognized as important in the development and maintenance of breast cancer. The family currently consists of four closely related members: the epidermal growth factor receptor (EGF-R/erbB-1), erbB-2, erbB-3 and erbB-4. Putative ligands which bind directly to or indirectly activate erbB-2/3/4 have been characterized recently. This still growing family of EGF-related growth factors includes gp30, its homolog heregulin (HRG), the rat homolog neu differentiation factor (NDF), glial growth factors (GLIA), ARIA and a 50 kDa factor from COLO 16 cells. The understanding of the function, biology and interactions of these growth factor receptors and their ligands will have far-reaching implications for the prognosis and treatment of breast cancer. This review focuses on advances and future directions for further investigations intended to clarify the mechanism and significance of erbB/ligand interactions in breast cancer.

Original languageEnglish (US)
Pages (from-to)135-145
Number of pages11
JournalSeminars in Cancer Biology
Volume6
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Neuregulin-1
Drug Resistance
Growth Factor Receptors
Breast Neoplasms
Ligands
Epidermal Growth Factor
Epidermal Growth Factor Receptor
Intercellular Signaling Peptides and Proteins
Maintenance
ErbB Receptors

Keywords

  • Breast cancer
  • erbB
  • Growth factor
  • Heregulin
  • Oncogene
  • Receptors

ASJC Scopus subject areas

  • Cancer Research

Cite this

Interaction between erbB- receptors and heregulin in breast cancer tumor progression and drug resistance. / Lupu, Ruth; Cardillo, Marina; Harris, Lyndsay; Hijazi, Mai; Rosenberg, Karen.

In: Seminars in Cancer Biology, Vol. 6, No. 3, 1995, p. 135-145.

Research output: Contribution to journalArticle

Lupu, Ruth ; Cardillo, Marina ; Harris, Lyndsay ; Hijazi, Mai ; Rosenberg, Karen. / Interaction between erbB- receptors and heregulin in breast cancer tumor progression and drug resistance. In: Seminars in Cancer Biology. 1995 ; Vol. 6, No. 3. pp. 135-145.
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