TY - JOUR
T1 - Intellectual functioning in presurgical patients with hypothalamic hamartoma and refractory epilepsy
AU - Prigatano, George P.
AU - Wethe, Jennifer V.
AU - Gray, Jennifer A.
AU - Wang, Norman
AU - Chung, Steven
AU - Ng, Yu Tze
AU - Prenger, Erin
AU - Kerrigan, John F.
N1 - Funding Information:
The authors thank Roger Johnsonbaugh, M.D., and Harold Rekate, M.D., for their help in classifying patients and in data analysis. This research was in part funded by the Barrow Neurological Foundation. Funding provided to the senior author through the Newsome Chair provided time to prepare this article. Special thanks go to Mary Henry and Eve DeShazer for their expert secretarial help.
PY - 2008/7
Y1 - 2008/7
N2 - Objective: The goal of the work described here was to examine the relationship between intellectual test performance in patients with hypothalamic hamartoma (HH) with refractory epilepsy and their seizure histories, as well as the size and neuroradiographic anatomical features of the HH. It was predicted that the level of estimated intelligence and the pattern of intellectual test performance would significantly correlate with the size of the HH and neuroanatomical features. Method: In this cross-sectional design study, 49 patients with HH between the ages of 5 and 55 years were classified by age at time of examination, as well as pattern of performance on the Wechsler intelligence scales. All patients were included in data analysis irrespective of their ability to participate in psychometric testing. Patients with a prior history of neurosurgical treatment were excluded. Results: For those patients functionally capable of participating in cognitive testing (n = 42), a summary index score, which estimated level of intellectual function (composed of the Vocabulary, Block Design, and Coding subtests of the Wechsler intelligence scales), was significantly correlated only with number of antiepileptic drugs (AEDs) the patient was taking at the time of evaluation (r = -0.66, n = 38, P = 0.05). In contrast, a categorization method addressing the pattern of intellectual test performance (including those patients who were not functionally capable of participating in cognitive testing, n = 49) was significantly correlated with number of AEDs (r = +0.35, n = 48, P = 0.01), size of HH (r = +0.38, n = 49, P = 0.01), presence of precocious puberty (PP: r = +0.41, n = 49, P = 0.01), and anatomical classification of HH (r = +0.39, n = 49, P = 0.01). Conclusions: The findings confirm the wide range of cognitive functioning in the population of patients with HH and refractory epilepsy, and suggest that multiple variables are correlated with intellectual test performance in patients with HH with refractory epilepsy. Although the present cross-sectional design study does not answer the question of whether or not epilepsy severity produces lower intelligence in this patient population, number of AEDs and neuroanatomical features of the HH lesion are identified as being significantly related to cognitive performance in this patient sample.
AB - Objective: The goal of the work described here was to examine the relationship between intellectual test performance in patients with hypothalamic hamartoma (HH) with refractory epilepsy and their seizure histories, as well as the size and neuroradiographic anatomical features of the HH. It was predicted that the level of estimated intelligence and the pattern of intellectual test performance would significantly correlate with the size of the HH and neuroanatomical features. Method: In this cross-sectional design study, 49 patients with HH between the ages of 5 and 55 years were classified by age at time of examination, as well as pattern of performance on the Wechsler intelligence scales. All patients were included in data analysis irrespective of their ability to participate in psychometric testing. Patients with a prior history of neurosurgical treatment were excluded. Results: For those patients functionally capable of participating in cognitive testing (n = 42), a summary index score, which estimated level of intellectual function (composed of the Vocabulary, Block Design, and Coding subtests of the Wechsler intelligence scales), was significantly correlated only with number of antiepileptic drugs (AEDs) the patient was taking at the time of evaluation (r = -0.66, n = 38, P = 0.05). In contrast, a categorization method addressing the pattern of intellectual test performance (including those patients who were not functionally capable of participating in cognitive testing, n = 49) was significantly correlated with number of AEDs (r = +0.35, n = 48, P = 0.01), size of HH (r = +0.38, n = 49, P = 0.01), presence of precocious puberty (PP: r = +0.41, n = 49, P = 0.01), and anatomical classification of HH (r = +0.39, n = 49, P = 0.01). Conclusions: The findings confirm the wide range of cognitive functioning in the population of patients with HH and refractory epilepsy, and suggest that multiple variables are correlated with intellectual test performance in patients with HH with refractory epilepsy. Although the present cross-sectional design study does not answer the question of whether or not epilepsy severity produces lower intelligence in this patient population, number of AEDs and neuroanatomical features of the HH lesion are identified as being significantly related to cognitive performance in this patient sample.
KW - Epilepsy
KW - Hypothalamic hamartoma
KW - Intellectual test performance
KW - Neuroanatomical features
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U2 - 10.1016/j.yebeh.2008.02.016
DO - 10.1016/j.yebeh.2008.02.016
M3 - Article
C2 - 18375185
AN - SCOPUS:46549085947
SN - 1525-5050
VL - 13
SP - 149
EP - 155
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 1
ER -