Integrin β3 links therapy resistance and cancer stem cell properties

Nagarajan Kannan; Long V. Nguyen; Connie J. Eaves

doi:10.1038/ncb2960

Integrin β3 links therapy resistance and cancer stem cell properties

Nagarajan Kannan, Long V. Nguyen, Connie J. Eaves

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin Î± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

Original language	English (US)
Pages (from-to)	397-399
Number of pages	3
Journal	Nature Cell Biology
Volume	16
Issue number	5
DOIs	https://doi.org/10.1038/ncb2960
State	Published - Jan 1 2014

ASJC Scopus subject areas

Cell Biology

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title = "Integrin β3 links therapy resistance and cancer stem cell properties",

abstract = "Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin {\^I}± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.",

author = "Nagarajan Kannan and Nguyen, {Long V.} and Eaves, {Connie J.}",

year = "2014",

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AU - Kannan, Nagarajan

AU - Nguyen, Long V.

AU - Eaves, Connie J.

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N2 - Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin Î± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

AB - Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin Î± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

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JO - Nature Cell Biology

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Integrin β3 links therapy resistance and cancer stem cell properties

Abstract

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