Integrin β3 links therapy resistance and cancer stem cell properties

Nagarajan Kannan; Long V. Nguyen; Connie J. Eaves

doi:10.1038/ncb2960

Integrin β3 links therapy resistance and cancer stem cell properties

Nagarajan Kannan, Long V. Nguyen, Connie J. Eaves

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin Î± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

Original language	English (US)
Pages (from-to)	397-399
Number of pages	3
Journal	Nature Cell Biology
Volume	16
Issue number	5
DOIs	https://doi.org/10.1038/ncb2960
State	Published - 2014

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1038/ncb2960

Cite this

@article{5c6070ca8c1e434ba011fd5f0d2ca7b1,

title = "Integrin β3 links therapy resistance and cancer stem cell properties",

abstract = "Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin {\^I}± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.",

author = "Nagarajan Kannan and Nguyen, {Long V.} and Eaves, {Connie J.}",

year = "2014",

doi = "10.1038/ncb2960",

language = "English (US)",

volume = "16",

pages = "397--399",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Integrin β3 links therapy resistance and cancer stem cell properties

AU - Kannan, Nagarajan

AU - Nguyen, Long V.

AU - Eaves, Connie J.

PY - 2014

Y1 - 2014

N2 - Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin Î± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

AB - Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin Î± v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

UR - http://www.scopus.com/inward/record.url?scp=84899847639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899847639&partnerID=8YFLogxK

U2 - 10.1038/ncb2960

DO - 10.1038/ncb2960

M3 - Review article

C2 - 24914436

AN - SCOPUS:84899847639

SN - 1465-7392

VL - 16

SP - 397

EP - 399

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 5

ER -

Integrin β3 links therapy resistance and cancer stem cell properties

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this