Integration of hormonal agents and chemotherapy for the treatment of women with advanced breast cancer

J. N. Ingle

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3 Citations (Scopus)

Abstract

Efforts have been made to improve the efficacy of combination chemotherapeutic regimens for advanced breast cancer by integrating additive hormonal agents. Results with respect to the value of such an approach are conflicting and the routine use of chemohormonal therapy in clinical practice has not been established. Further work in this area is needed especially in regard to the use of hormonal agents as manipulators of tumor cell kinetics to enhance the effectiveness of chemotherapy. In addition, clinical trials have compared the results of hormonal therapy alone with those of chemohormonal therapy; currently, the use of hormonal agents alone seems to be preferable for the initial treatment of most postmenopausal women with advanced breast cancer. The exception to this practice would be in those patients who are clinically no candidates for hormonal therapy because of the site, extent, or tempo of disease or because of the absence of hormonal receptors.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalMayo Clinic Proceedings
Volume59
Issue number4
StatePublished - 1984

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Breast Neoplasms
Drug Therapy
Therapeutics
Clinical Trials
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Integration of hormonal agents and chemotherapy for the treatment of women with advanced breast cancer. / Ingle, J. N.

In: Mayo Clinic Proceedings, Vol. 59, No. 4, 1984, p. 232-238.

Research output: Contribution to journalArticle

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