Integrate and boost: Bioscaffolds nurture the cardiac regenerative paradigm

Jozef Bartunek, Marc Vanderheyden, Atta Behfar

Research output: Contribution to journalReview article

Abstract

The traditional cardiac regenerative paradigm using non-modified adult stem cells with various routes of delivery into the myocardial target has thus far yielded unconvincing clinical outcomes. Besides factors related to heterogeneity in trial methodology, inter-patient variability and the rare incidence of adult stem cells with intrinsic repair potency underscore the importance of further optimization and standardization of regenerative platforms. Cardiac tissue engineering seizing upon the advances of cellular, molecular, and biomaterial development is shaping the next generation of the regenerative paradigm and thereby fostering disruptive curative treatments in heart failure.

Original languageEnglish (US)
Article number183
JournalStem Cell Research and Therapy
Volume6
Issue number1
DOIs
StatePublished - Sep 23 2015

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Adult Stem Cells
Stem cells
Seizing
Foster Home Care
Biocompatible Materials
Tissue Engineering
Tissue engineering
Standardization
Repair
Heart Failure
Incidence
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Medicine
  • Cell Biology
  • Medicine (miscellaneous)

Cite this

Integrate and boost : Bioscaffolds nurture the cardiac regenerative paradigm. / Bartunek, Jozef; Vanderheyden, Marc; Behfar, Atta.

In: Stem Cell Research and Therapy, Vol. 6, No. 1, 183, 23.09.2015.

Research output: Contribution to journalReview article

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