Intake of coffee, caffeine and other methylxanthines and risk of Type i vs Type II endometrial cancer

S. Uccella, A. Mariani, A. H. Wang, R. A. Vierkant, William Arthur Cliby, K. Robien, K. E. Anderson, James R Cerhan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background:Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.Methods: Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases.Results:Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m-2 (RR=0.56; 95% CI: 0.36-0.89).Conclusion:Coffee may protect against Type I EC in obese postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1908-1913
Number of pages6
JournalBritish Journal of Cancer
Volume109
Issue number7
DOIs
StatePublished - Oct 1 2013

Fingerprint

Coffee
Endometrial Neoplasms
Caffeine
Confidence Intervals
Tea
Body Mass Index
methylxanthine

Keywords

  • caffeine
  • coffee
  • cola
  • decaffeinated coffee
  • endometrial cancer
  • methylxanthines
  • tea

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Intake of coffee, caffeine and other methylxanthines and risk of Type i vs Type II endometrial cancer. / Uccella, S.; Mariani, A.; Wang, A. H.; Vierkant, R. A.; Cliby, William Arthur; Robien, K.; Anderson, K. E.; Cerhan, James R.

In: British Journal of Cancer, Vol. 109, No. 7, 01.10.2013, p. 1908-1913.

Research output: Contribution to journalArticle

Uccella, S. ; Mariani, A. ; Wang, A. H. ; Vierkant, R. A. ; Cliby, William Arthur ; Robien, K. ; Anderson, K. E. ; Cerhan, James R. / Intake of coffee, caffeine and other methylxanthines and risk of Type i vs Type II endometrial cancer. In: British Journal of Cancer. 2013 ; Vol. 109, No. 7. pp. 1908-1913.
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AU - Anderson, K. E.

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