Intact blood pressure, but not sympathetic, responsiveness to sympathoexcitatory stimuli in a patient with unilateral carotid body resection

Kathryn F. Larson, Jacqueline K. Limberg, Sarah E. Baker, Michael Joseph Joyner, Timothy B Curry

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Despite rapidly growing interest in the therapeutic resection of the carotid body (CB) chemoreceptors, few physiologic studies exist on the consequences of unilateral CB resection. We present a case of an otherwise healthy postmenopausal female who underwent unilateral CB resection for a paraganglioma. Approximately 4 years postoperatively, she underwent analysis of her sympathetic and hemodynamic responses to hypoxia, lower body negative pressure, cold pressor test (CPT), and ischemic hand grip exercise and postexercise ischemia (IHE/PEI). Hypoxic ventilatory response and baroreflex sensitivity were relatively normal. Hemodynamic responses to IHE/PEI and CPT showed characteristic increases in cardiac output (from 3.9 L/min to 5.2 L/min [IHE/PEI] and 4.9 L/min [CPT]) and blood pressure (from 126/72 mmHg to 161/87 mmHg [IHE/PEI] and 171/93 mmHg [CPT]). However, muscle sympathetic nerve activity (microneurography of the peroneal nerve) decreased from baseline during IHE/PEI and CPT (burst incidence nadir of 45% and 40% of baseline, respectively) and there was no observable change in total peripheral resistance (from 24 mmHg*min/L to 22 mmHg*min/L [IHE/PEI] and 25 mmHg*min/L [CPT]). These findings illustrate intact blood pressure responsiveness despite attenuated sympathoexcitation, possibly due to an increase in cardiac output and/or adaptive inhibitory effect of the baroreflex on peripheral sympathetic activity.

Original languageEnglish (US)
Article numbere13212
JournalPhysiological Reports
Volume5
Issue number7
DOIs
StatePublished - Apr 1 2017

Fingerprint

Carotid Body
Hand Strength
Hand
Exercise
Blood Pressure
Ischemia
Cold Ischemia
Baroreflex
Cardiac Output
Hemodynamics
Lower Body Negative Pressure
Paraganglioma
Peroneal Nerve
Vascular Resistance
Muscles
Incidence

Keywords

  • Baroreflex sensitivity
  • carotid chemoreceptor
  • hypoxic ventilatory response
  • muscle sympathetic nerve activity

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

Cite this

Intact blood pressure, but not sympathetic, responsiveness to sympathoexcitatory stimuli in a patient with unilateral carotid body resection. / Larson, Kathryn F.; Limberg, Jacqueline K.; Baker, Sarah E.; Joyner, Michael Joseph; Curry, Timothy B.

In: Physiological Reports, Vol. 5, No. 7, e13212, 01.04.2017.

Research output: Contribution to journalArticle

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