Insulin regulation of regional free fatty acid metabolism

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Studies were conducted to determine whether regional free fatty acid (FFA) release is differentially regulated by insulin. Systemic, leg, and splanchnic palmitate rate of appearance ([9,10-3H]palmitate) was measured in 26 healthy adults using the euglycemic-hyperinsulinemic clamp technique to achieve a physiological range of plasma insulin concentrations. We found that insulin inhibited systemic, leg, and splanchnic palmitate release in a dose- dependent fashion over the range of insulin infused (0-1.0 mU · kg-1 · min-1). Progressive hyperinsulinemia changed the leg from a net producer to a net FFA consumer, whereas the splanchnic bed converted from a net FFA consumer to a net producer. At the 0.5 mU · kg-1 · min-1 insulin infusion rate, leg FFA release was almost completely suppressed, whereas even with the 1.0 mU · kg-1 · min-1 insulin infusion rate, splanchnic FFA release decreased by only ~65% (P < 0.05 leg vs. splanchnic). These results demonstrate the regional heterogeneity of insulin-regulated FFA release in vivo, and indicate that visceral adipose tissue lipolysis is more resistant to insulin suppression than is leg lipolysis in humans.

Original languageEnglish (US)
Pages (from-to)10-14
Number of pages5
JournalDiabetes
Volume48
Issue number1
DOIs
StatePublished - Jan 1999

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Nonesterified Fatty Acids
Viscera
Insulin
Leg
Palmitates
Lipolysis
Glucose Clamp Technique
Intra-Abdominal Fat
Hyperinsulinism

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Insulin regulation of regional free fatty acid metabolism. / Meek, Shon E.; Nair, K Sreekumaran; Jensen, Michael Dennis.

In: Diabetes, Vol. 48, No. 1, 01.1999, p. 10-14.

Research output: Contribution to journalArticle

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