TY - JOUR
T1 - Insulin-like growth factor I, insulin-like growth factor binding protein 3, and urologic measures of benign prostatic hyperplasia
AU - Roberts, Rosebud O.
AU - Jacobson, Debra J.
AU - Girman, Cynthia J.
AU - Rhodes, Thomas
AU - Klee, George G.
AU - Lieber, Michael M.
AU - Jacobsen, Steven J.
N1 - Funding Information:
This project was supported by research grants from the Public Health Service, National Institutes of Health (DK58859 and AR30582), and Merck Research Laboratories.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Laboratory studies suggest that insulin-like growth factor I (IGF-I) promotes prostatic growth. The authors evaluated the association between benign prostatic hyperplasia and IGF-I and its binding protein IGFBP-3 in community-dwelling men to determine whether this laboratory finding is manifest at the population level. Participants (n = 471) were Olmsted County, Minnesota, Caucasian males aged 40-79 years in 1990. Urologic measures were assessed from the International Prostate Symptom Score, peak urinary flow rates, prostate volume, and serum prostate-specific antigen (PSA), and serum IGF-I and IGFBP-3 levels were measured. After adjustment for age, the relative odds (odds ratios) of an abnormal urologic measure in men with high versus low serum IGF-I levels were 0.98 (95% confidence interval (Cl): 0.66, 1.45) for a symptom score of >7, 1.14 (95% Cl: 0.72, 1.80) for a peak urinary flow rate of <12 mi/second, 1.11 (95% Cl: 0.72, 1.72) for a prostate volume of <30 mi, and 0.71 (95% Cl: 0.46, 1.09) for a PSA level of <1.4 ng/ml. A low IGFBP-3 level was associated with an enlarged prostate (odds ratio = 1.72, 95% Cl: 1.05, 2.82), after simultaneous adjustment for IGF-I and age, but not with other urologic measures. These data do not provide evidence for an association between benign prostatic hyperplasia and serum IGF-I.
AB - Laboratory studies suggest that insulin-like growth factor I (IGF-I) promotes prostatic growth. The authors evaluated the association between benign prostatic hyperplasia and IGF-I and its binding protein IGFBP-3 in community-dwelling men to determine whether this laboratory finding is manifest at the population level. Participants (n = 471) were Olmsted County, Minnesota, Caucasian males aged 40-79 years in 1990. Urologic measures were assessed from the International Prostate Symptom Score, peak urinary flow rates, prostate volume, and serum prostate-specific antigen (PSA), and serum IGF-I and IGFBP-3 levels were measured. After adjustment for age, the relative odds (odds ratios) of an abnormal urologic measure in men with high versus low serum IGF-I levels were 0.98 (95% confidence interval (Cl): 0.66, 1.45) for a symptom score of >7, 1.14 (95% Cl: 0.72, 1.80) for a peak urinary flow rate of <12 mi/second, 1.11 (95% Cl: 0.72, 1.72) for a prostate volume of <30 mi, and 0.71 (95% Cl: 0.46, 1.09) for a PSA level of <1.4 ng/ml. A low IGFBP-3 level was associated with an enlarged prostate (odds ratio = 1.72, 95% Cl: 1.05, 2.82), after simultaneous adjustment for IGF-I and age, but not with other urologic measures. These data do not provide evidence for an association between benign prostatic hyperplasia and serum IGF-I.
KW - Insulin-like growth factor I
KW - Insulin-like growth factor binding protein 3
KW - Men
KW - Prostate-specific antigen
KW - Prostatic hyperplasia
KW - Urological manifestations
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U2 - 10.1093/aje/kwf054
DO - 10.1093/aje/kwf054
M3 - Article
C2 - 12727672
AN - SCOPUS:0038416674
SN - 0002-9262
VL - 157
SP - 784
EP - 791
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 9
ER -