Insulin-like growth factor I, insulin-like growth factor binding protein 3, and urologic measures of benign prostatic hyperplasia

Rosebud O. Roberts, Debra J. Jacobson, Cynthia J. Girman, Thomas Rhodes, George G. Klee, Michael M. Lieber, Steven J. Jacobsen

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Laboratory studies suggest that insulin-like growth factor I (IGF-I) promotes prostatic growth. The authors evaluated the association between benign prostatic hyperplasia and IGF-I and its binding protein IGFBP-3 in community-dwelling men to determine whether this laboratory finding is manifest at the population level. Participants (n = 471) were Olmsted County, Minnesota, Caucasian males aged 40-79 years in 1990. Urologic measures were assessed from the International Prostate Symptom Score, peak urinary flow rates, prostate volume, and serum prostate-specific antigen (PSA), and serum IGF-I and IGFBP-3 levels were measured. After adjustment for age, the relative odds (odds ratios) of an abnormal urologic measure in men with high versus low serum IGF-I levels were 0.98 (95% confidence interval (Cl): 0.66, 1.45) for a symptom score of >7, 1.14 (95% Cl: 0.72, 1.80) for a peak urinary flow rate of <12 mi/second, 1.11 (95% Cl: 0.72, 1.72) for a prostate volume of <30 mi, and 0.71 (95% Cl: 0.46, 1.09) for a PSA level of <1.4 ng/ml. A low IGFBP-3 level was associated with an enlarged prostate (odds ratio = 1.72, 95% Cl: 1.05, 2.82), after simultaneous adjustment for IGF-I and age, but not with other urologic measures. These data do not provide evidence for an association between benign prostatic hyperplasia and serum IGF-I.

Original languageEnglish (US)
Pages (from-to)784-791
Number of pages8
JournalAmerican journal of epidemiology
Volume157
Issue number9
DOIs
StatePublished - May 1 2003

Keywords

  • Insulin-like growth factor I
  • Insulin-like growth factor binding protein 3
  • Men
  • Prostate-specific antigen
  • Prostatic hyperplasia
  • Urological manifestations

ASJC Scopus subject areas

  • Epidemiology

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