Insulin-like growth factor I, insulin-like growth factor binding protein 3, and urologic measures of benign prostatic hyperplasia

Rosebud O Roberts, Debra J. Jacobson, Cynthia J. Girman, Thomas Rhodes, George G. Klee, Michael M. Lieber, Steven J. Jacobsen

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Abstract

Laboratory studies suggest that insulin-like growth factor I (IGF-I) promotes prostatic growth. The authors evaluated the association between benign prostatic hyperplasia and IGF-I and its binding protein IGFBP-3 in community-dwelling men to determine whether this laboratory finding is manifest at the population level. Participants (n = 471) were Olmsted County, Minnesota, Caucasian males aged 40-79 years in 1990. Urologic measures were assessed from the International Prostate Symptom Score, peak urinary flow rates, prostate volume, and serum prostate-specific antigen (PSA), and serum IGF-I and IGFBP-3 levels were measured. After adjustment for age, the relative odds (odds ratios) of an abnormal urologic measure in men with high versus low serum IGF-I levels were 0.98 (95% confidence interval (Cl): 0.66, 1.45) for a symptom score of >7, 1.14 (95% Cl: 0.72, 1.80) for a peak urinary flow rate of <12 mi/second, 1.11 (95% Cl: 0.72, 1.72) for a prostate volume of <30 mi, and 0.71 (95% Cl: 0.46, 1.09) for a PSA level of <1.4 ng/ml. A low IGFBP-3 level was associated with an enlarged prostate (odds ratio = 1.72, 95% Cl: 1.05, 2.82), after simultaneous adjustment for IGF-I and age, but not with other urologic measures. These data do not provide evidence for an association between benign prostatic hyperplasia and serum IGF-I.

Original languageEnglish (US)
Pages (from-to)784-791
Number of pages8
JournalAmerican Journal of Epidemiology
Volume157
Issue number9
DOIs
StatePublished - May 1 2003

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Keywords

  • Insulin-like growth factor binding protein 3
  • Insulin-like growth factor I
  • Men
  • Prostate-specific antigen
  • Prostatic hyperplasia
  • Urological manifestations

ASJC Scopus subject areas

  • Epidemiology

Cite this

Roberts, R. O., Jacobson, D. J., Girman, C. J., Rhodes, T., Klee, G. G., Lieber, M. M., & Jacobsen, S. J. (2003). Insulin-like growth factor I, insulin-like growth factor binding protein 3, and urologic measures of benign prostatic hyperplasia. American Journal of Epidemiology, 157(9), 784-791. https://doi.org/10.1093/aje/kwf054