TY - JOUR
T1 - Insulin-like growth factor-binding proteins and bone metabolism
AU - Conover, Cheryl A.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/1
Y1 - 2008/1
N2 - Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and posttranslational modifications, as well as IGF-independent effects. This review focuses on recent findings from cell culture, rodent models, and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone.
AB - Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and posttranslational modifications, as well as IGF-independent effects. This review focuses on recent findings from cell culture, rodent models, and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone.
KW - Insulin-like growth factors
UR - http://www.scopus.com/inward/record.url?scp=38349026590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349026590&partnerID=8YFLogxK
U2 - 10.1152/ajpendo.00648.2007
DO - 10.1152/ajpendo.00648.2007
M3 - Review article
C2 - 18003717
AN - SCOPUS:38349026590
SN - 0193-1849
VL - 294
SP - E10-E14
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 1
ER -