Insulin causes vasoconstriction but does not increase blood pressure in the elderly

M. Hausberg, R. P. Hoftman, Virend Somers, C. A. Sinkev, A. L. Mark, E. A. Anderson

Research output: Contribution to journalArticle

Abstract

Objective: Acute increases in plasma insulin (pINS) produce both sympathoexcitation and vasodilation in normal young adults. However, aging is associated with insulin resistance and maybe altered vascular and/or sympatheticresponses to insulin. Degign and Methods: Muscle sympathetic nerve activity (MSNA, microneurogaphy), forearm blood flow (FBF), blood pressure (HP) and heart rate (HR) responses to acute pINS increases were assessed in healthy, lean, normotensive elderly (ELD, N=l 1, BMI=25±lkg/m2, age=64±2y) and young (YNG. N=8, BMI=26±lkg/m2, age=27±2y) subjects. Data were collected during a 90 min insulin clamp. Data are mean ±SE. Results pINS(μU/ml) M-Value Mean, BP(mmHg) HR(beats/min) MSHA(b/min) Gruop control clamp (mg/kg mini control clamp ccptrot clamp control clamp ELD 9±2 88±104.3±0.4 95±2 94±2 62±2 63±2 33±3 44+4YNG 9±2 83+. 68,3±1.5t 84±2 a 86±2 a 61±3 65±315±2t 3l±4,ap<0.05 (clamp vs control) a p<0.05 (ELD vs YNG) Conclusions: 1) ELD show vasoconstriction, noi vasodifation, with insulin. 2) ELD have elevated resting MSNA but attenuated insulin-induced increases in MSNA. 3} BP did not increase with insulin in either group. 4) ELD lack the increased HR observed in the YNG. 5) ELD are more insulin resistant. The absence of vasodilation with insulin in the ELD may contribute to their insulin resistance by reducing glucose delivery. The vasoconstriction in the ELD is not due to exaggerated MSNA but to a failure of insulin's vasodilator action.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

vasoconstriction
Blood pressure
Vasoconstriction
blood pressure
insulin
Insulin
Blood Pressure
Clamping devices
insulin resistance
heart rate
vasodilation
Heart Rate
Vasodilation
Insulin Resistance
Plasmas
vasodilator agents
Vasodilator Agents
young adults
blood vessels
Forearm

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Hausberg, M., Hoftman, R. P., Somers, V., Sinkev, C. A., Mark, A. L., & Anderson, E. A. (1996). Insulin causes vasoconstriction but does not increase blood pressure in the elderly. FASEB Journal, 10(3).

Insulin causes vasoconstriction but does not increase blood pressure in the elderly. / Hausberg, M.; Hoftman, R. P.; Somers, Virend; Sinkev, C. A.; Mark, A. L.; Anderson, E. A.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Hausberg, M, Hoftman, RP, Somers, V, Sinkev, CA, Mark, AL & Anderson, EA 1996, 'Insulin causes vasoconstriction but does not increase blood pressure in the elderly', FASEB Journal, vol. 10, no. 3.
Hausberg M, Hoftman RP, Somers V, Sinkev CA, Mark AL, Anderson EA. Insulin causes vasoconstriction but does not increase blood pressure in the elderly. FASEB Journal. 1996;10(3).
Hausberg, M. ; Hoftman, R. P. ; Somers, Virend ; Sinkev, C. A. ; Mark, A. L. ; Anderson, E. A. / Insulin causes vasoconstriction but does not increase blood pressure in the elderly. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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abstract = "Objective: Acute increases in plasma insulin (pINS) produce both sympathoexcitation and vasodilation in normal young adults. However, aging is associated with insulin resistance and maybe altered vascular and/or sympatheticresponses to insulin. Degign and Methods: Muscle sympathetic nerve activity (MSNA, microneurogaphy), forearm blood flow (FBF), blood pressure (HP) and heart rate (HR) responses to acute pINS increases were assessed in healthy, lean, normotensive elderly (ELD, N=l 1, BMI=25±lkg/m2, age=64±2y) and young (YNG. N=8, BMI=26±lkg/m2, age=27±2y) subjects. Data were collected during a 90 min insulin clamp. Data are mean ±SE. Results pINS(μU/ml) M-Value Mean, BP(mmHg) HR(beats/min) MSHA(b/min) Gruop control clamp (mg/kg mini control clamp ccptrot clamp control clamp ELD 9±2 88±104.3±0.4 95±2 94±2 62±2 63±2 33±3 44+4YNG 9±2 83+. 68,3±1.5t 84±2 a 86±2 a 61±3 65±315±2t 3l±4,ap<0.05 (clamp vs control) a p<0.05 (ELD vs YNG) Conclusions: 1) ELD show vasoconstriction, noi vasodifation, with insulin. 2) ELD have elevated resting MSNA but attenuated insulin-induced increases in MSNA. 3} BP did not increase with insulin in either group. 4) ELD lack the increased HR observed in the YNG. 5) ELD are more insulin resistant. The absence of vasodilation with insulin in the ELD may contribute to their insulin resistance by reducing glucose delivery. The vasoconstriction in the ELD is not due to exaggerated MSNA but to a failure of insulin's vasodilator action.",
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AU - Hausberg, M.

AU - Hoftman, R. P.

AU - Somers, Virend

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AU - Mark, A. L.

AU - Anderson, E. A.

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N2 - Objective: Acute increases in plasma insulin (pINS) produce both sympathoexcitation and vasodilation in normal young adults. However, aging is associated with insulin resistance and maybe altered vascular and/or sympatheticresponses to insulin. Degign and Methods: Muscle sympathetic nerve activity (MSNA, microneurogaphy), forearm blood flow (FBF), blood pressure (HP) and heart rate (HR) responses to acute pINS increases were assessed in healthy, lean, normotensive elderly (ELD, N=l 1, BMI=25±lkg/m2, age=64±2y) and young (YNG. N=8, BMI=26±lkg/m2, age=27±2y) subjects. Data were collected during a 90 min insulin clamp. Data are mean ±SE. Results pINS(μU/ml) M-Value Mean, BP(mmHg) HR(beats/min) MSHA(b/min) Gruop control clamp (mg/kg mini control clamp ccptrot clamp control clamp ELD 9±2 88±104.3±0.4 95±2 94±2 62±2 63±2 33±3 44+4YNG 9±2 83+. 68,3±1.5t 84±2 a 86±2 a 61±3 65±315±2t 3l±4,ap<0.05 (clamp vs control) a p<0.05 (ELD vs YNG) Conclusions: 1) ELD show vasoconstriction, noi vasodifation, with insulin. 2) ELD have elevated resting MSNA but attenuated insulin-induced increases in MSNA. 3} BP did not increase with insulin in either group. 4) ELD lack the increased HR observed in the YNG. 5) ELD are more insulin resistant. The absence of vasodilation with insulin in the ELD may contribute to their insulin resistance by reducing glucose delivery. The vasoconstriction in the ELD is not due to exaggerated MSNA but to a failure of insulin's vasodilator action.

AB - Objective: Acute increases in plasma insulin (pINS) produce both sympathoexcitation and vasodilation in normal young adults. However, aging is associated with insulin resistance and maybe altered vascular and/or sympatheticresponses to insulin. Degign and Methods: Muscle sympathetic nerve activity (MSNA, microneurogaphy), forearm blood flow (FBF), blood pressure (HP) and heart rate (HR) responses to acute pINS increases were assessed in healthy, lean, normotensive elderly (ELD, N=l 1, BMI=25±lkg/m2, age=64±2y) and young (YNG. N=8, BMI=26±lkg/m2, age=27±2y) subjects. Data were collected during a 90 min insulin clamp. Data are mean ±SE. Results pINS(μU/ml) M-Value Mean, BP(mmHg) HR(beats/min) MSHA(b/min) Gruop control clamp (mg/kg mini control clamp ccptrot clamp control clamp ELD 9±2 88±104.3±0.4 95±2 94±2 62±2 63±2 33±3 44+4YNG 9±2 83+. 68,3±1.5t 84±2 a 86±2 a 61±3 65±315±2t 3l±4,ap<0.05 (clamp vs control) a p<0.05 (ELD vs YNG) Conclusions: 1) ELD show vasoconstriction, noi vasodifation, with insulin. 2) ELD have elevated resting MSNA but attenuated insulin-induced increases in MSNA. 3} BP did not increase with insulin in either group. 4) ELD lack the increased HR observed in the YNG. 5) ELD are more insulin resistant. The absence of vasodilation with insulin in the ELD may contribute to their insulin resistance by reducing glucose delivery. The vasoconstriction in the ELD is not due to exaggerated MSNA but to a failure of insulin's vasodilator action.

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