Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso

Pegdwendé Abel Sorgho, Jeremy James Martinson, Florencia Wendkuuni Djigma, Albert Théophane Yonli, Bolni Nagalo, Tegwinde Rebeca Compaore, Dorcas Obiri-Yeboah, Birama Diarra, Herman Karim Sombie, Arsène Wendpagnangdé Zongo, Abdoul Karim Ouattara, Serge Théophile R. Soubeiga, Lassina Traore, Lewis Rowland Roberts, Jacques Simpore

Research output: Contribution to journalArticle

Abstract

Background/Objective: Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC).The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection. Methods: Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes. Results: The study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82; p 0.001), KIR2DL3 (crude OR = 2.49; p 0.001) and activator gene KIR2DS2 (crude OR = 3.95; p 0.001) might be associated with chronic stages of HBV infection. Conversely the inhibitory genes KIR3DL1 (crude OR = 0.49; p = 0.0018) and KIR3DL2 (crude OR = 0.41; p = 0.005), the activator gene KIR2DS1 (crude OR = 0.48; p = 0.014) and the pseudo gene KIR2DP1 (crude OR = 0.49; p = 0.008) could be associated with immunity against HBV infection. Chronic HBV patients who are carriers for the KIR3DL3 gene (crude OR = 8; p = 0.048) were positive for HBeAg and patients who carried the KIR3DL2 gene (crude OR = 3.21; p = 0.012) had a high HBV viral load compared to the rest of the study population. Conclusion: Our data showed evidence of a correlation between the risk of developing chronic HBV infection and certain KIR gene frequencies and also show that KIR3DL1, KIR3DL2, KIR2DS1 might confer a protective status against chronic HBV infection.

Original languageEnglish (US)
Article numbere2018060
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2018

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KIR Receptors
Burkina Faso
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Gene Frequency
Genes
Viral Load
Hepatitis B e Antigens
Hepatocellular Carcinoma
Immunity
Fibrosis

Keywords

  • Burkina Faso
  • Chronic hepatitis B
  • HBV
  • KIR

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

Cite this

Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso. / Sorgho, Pegdwendé Abel; Martinson, Jeremy James; Djigma, Florencia Wendkuuni; Yonli, Albert Théophane; Nagalo, Bolni; Compaore, Tegwinde Rebeca; Obiri-Yeboah, Dorcas; Diarra, Birama; Sombie, Herman Karim; Zongo, Arsène Wendpagnangdé; Ouattara, Abdoul Karim; Soubeiga, Serge Théophile R.; Traore, Lassina; Roberts, Lewis Rowland; Simpore, Jacques.

In: Mediterranean Journal of Hematology and Infectious Diseases, Vol. 10, No. 1, e2018060, 01.01.2018.

Research output: Contribution to journalArticle

Sorgho, PA, Martinson, JJ, Djigma, FW, Yonli, AT, Nagalo, B, Compaore, TR, Obiri-Yeboah, D, Diarra, B, Sombie, HK, Zongo, AW, Ouattara, AK, Soubeiga, STR, Traore, L, Roberts, LR & Simpore, J 2018, 'Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso', Mediterranean Journal of Hematology and Infectious Diseases, vol. 10, no. 1, e2018060. https://doi.org/10.4084/MJHID.2018.060
Sorgho, Pegdwendé Abel ; Martinson, Jeremy James ; Djigma, Florencia Wendkuuni ; Yonli, Albert Théophane ; Nagalo, Bolni ; Compaore, Tegwinde Rebeca ; Obiri-Yeboah, Dorcas ; Diarra, Birama ; Sombie, Herman Karim ; Zongo, Arsène Wendpagnangdé ; Ouattara, Abdoul Karim ; Soubeiga, Serge Théophile R. ; Traore, Lassina ; Roberts, Lewis Rowland ; Simpore, Jacques. / Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso. In: Mediterranean Journal of Hematology and Infectious Diseases. 2018 ; Vol. 10, No. 1.
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AU - Martinson, Jeremy James

AU - Djigma, Florencia Wendkuuni

AU - Yonli, Albert Théophane

AU - Nagalo, Bolni

AU - Compaore, Tegwinde Rebeca

AU - Obiri-Yeboah, Dorcas

AU - Diarra, Birama

AU - Sombie, Herman Karim

AU - Zongo, Arsène Wendpagnangdé

AU - Ouattara, Abdoul Karim

AU - Soubeiga, Serge Théophile R.

AU - Traore, Lassina

AU - Roberts, Lewis Rowland

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