Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso

Pegdwendé Abel Sorgho, Jeremy James Martinson, Florencia Wendkuuni Djigma, Albert Théophane Yonli, Bolni Marius Nagalo, Tegwinde Rebeca Compaore, Dorcas Obiri-Yeboah, Birama Diarra, Herman Karim Sombie, Arsène Wendpagnangdé Zongo, Abdoul Karim Ouattara, Serge Théophile R. Soubeiga, Lassina Traore, Lewis R. Roberts, Jacques Simpore

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background/Objective: Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC).The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection. Methods: Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes. Results: The study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82; p 0.001), KIR2DL3 (crude OR = 2.49; p 0.001) and activator gene KIR2DS2 (crude OR = 3.95; p 0.001) might be associated with chronic stages of HBV infection. Conversely the inhibitory genes KIR3DL1 (crude OR = 0.49; p = 0.0018) and KIR3DL2 (crude OR = 0.41; p = 0.005), the activator gene KIR2DS1 (crude OR = 0.48; p = 0.014) and the pseudo gene KIR2DP1 (crude OR = 0.49; p = 0.008) could be associated with immunity against HBV infection. Chronic HBV patients who are carriers for the KIR3DL3 gene (crude OR = 8; p = 0.048) were positive for HBeAg and patients who carried the KIR3DL2 gene (crude OR = 3.21; p = 0.012) had a high HBV viral load compared to the rest of the study population. Conclusion: Our data showed evidence of a correlation between the risk of developing chronic HBV infection and certain KIR gene frequencies and also show that KIR3DL1, KIR3DL2, KIR2DS1 might confer a protective status against chronic HBV infection.

Original languageEnglish (US)
Article numbere2018060
JournalMediterranean Journal of Hematology and Infectious Diseases
Issue number1
StatePublished - 2018


  • Burkina Faso
  • Chronic hepatitis B
  • HBV
  • KIR

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases


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