TY - JOUR
T1 - Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso
AU - Sorgho, Pegdwendé Abel
AU - Martinson, Jeremy James
AU - Djigma, Florencia Wendkuuni
AU - Yonli, Albert Théophane
AU - Nagalo, Bolni Marius
AU - Compaore, Tegwinde Rebeca
AU - Obiri-Yeboah, Dorcas
AU - Diarra, Birama
AU - Sombie, Herman Karim
AU - Zongo, Arsène Wendpagnangdé
AU - Ouattara, Abdoul Karim
AU - Soubeiga, Serge Théophile R.
AU - Traore, Lassina
AU - Roberts, Lewis R.
AU - Simpore, Jacques
N1 - Funding Information:
We would like to thank the Institute of International Education, the U.S. Department of State's Bureau of Educational and Cultural Affairs, The US embassy of Ouagadougou and the Council for International Exchange of Scholars (CIES) for funding this project through the J. William Fulbright Foreign Scholarship (African Research Scholar Program).
Publisher Copyright:
© 2018 Universita Cattolica del Sacro Cuore. All Rights Reserved.
PY - 2018
Y1 - 2018
N2 - Background/Objective: Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC).The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection. Methods: Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes. Results: The study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82; p 0.001), KIR2DL3 (crude OR = 2.49; p 0.001) and activator gene KIR2DS2 (crude OR = 3.95; p 0.001) might be associated with chronic stages of HBV infection. Conversely the inhibitory genes KIR3DL1 (crude OR = 0.49; p = 0.0018) and KIR3DL2 (crude OR = 0.41; p = 0.005), the activator gene KIR2DS1 (crude OR = 0.48; p = 0.014) and the pseudo gene KIR2DP1 (crude OR = 0.49; p = 0.008) could be associated with immunity against HBV infection. Chronic HBV patients who are carriers for the KIR3DL3 gene (crude OR = 8; p = 0.048) were positive for HBeAg and patients who carried the KIR3DL2 gene (crude OR = 3.21; p = 0.012) had a high HBV viral load compared to the rest of the study population. Conclusion: Our data showed evidence of a correlation between the risk of developing chronic HBV infection and certain KIR gene frequencies and also show that KIR3DL1, KIR3DL2, KIR2DS1 might confer a protective status against chronic HBV infection.
AB - Background/Objective: Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC).The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection. Methods: Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes. Results: The study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82; p 0.001), KIR2DL3 (crude OR = 2.49; p 0.001) and activator gene KIR2DS2 (crude OR = 3.95; p 0.001) might be associated with chronic stages of HBV infection. Conversely the inhibitory genes KIR3DL1 (crude OR = 0.49; p = 0.0018) and KIR3DL2 (crude OR = 0.41; p = 0.005), the activator gene KIR2DS1 (crude OR = 0.48; p = 0.014) and the pseudo gene KIR2DP1 (crude OR = 0.49; p = 0.008) could be associated with immunity against HBV infection. Chronic HBV patients who are carriers for the KIR3DL3 gene (crude OR = 8; p = 0.048) were positive for HBeAg and patients who carried the KIR3DL2 gene (crude OR = 3.21; p = 0.012) had a high HBV viral load compared to the rest of the study population. Conclusion: Our data showed evidence of a correlation between the risk of developing chronic HBV infection and certain KIR gene frequencies and also show that KIR3DL1, KIR3DL2, KIR2DS1 might confer a protective status against chronic HBV infection.
KW - Burkina Faso
KW - Chronic hepatitis B
KW - HBV
KW - KIR
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U2 - 10.4084/MJHID.2018.060
DO - 10.4084/MJHID.2018.060
M3 - Article
AN - SCOPUS:85060976411
SN - 2035-3006
VL - 10
JO - Mediterranean Journal of Hematology and Infectious Diseases
JF - Mediterranean Journal of Hematology and Infectious Diseases
IS - 1
M1 - e2018060
ER -