Insights into the Functional Anatomy Behind the PREEMPT Injection Paradigm

Guidance on Achieving Optimal Outcomes

Andrew M. Blumenfeld, Stephen D. Silberstein, David William Dodick, Sheena K. Aurora, Mitchell F. Brin, William J. Binder

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To provide clinically relevant insights on the identification of the muscles and techniques involved in the safe and effective use of onabotulinumtoxinA for chronic migraine prophylaxis. Background: Although guidance on the use of onabotulinumtoxinA for chronic migraine is available, based on the Phase III Research Evaluating Migraine Prophylaxis Therapy (PREEMPT) clinical program, clinical experience has shown that insufficient understanding of the anatomy and function of the head and neck muscles may lead to undesirable outcomes and suboptimal efficacy. Design/Methods: Each muscle involved in the standardized PREEMPT injection paradigm is reviewed with a thorough description of each muscle's anatomy (ie, muscle description and location, innervation, vascular supply) and function. Key insights based on clinical experience are also provided to help improve outcomes. Results: The identification of the muscles in the PREEMPT injection paradigm should be based on each patient's unique anatomy and injections should be administered using the advised techniques. A thorough examination of the patient prior to treatment is also critical to determine if any preexisting conditions may increase the risk for unwanted outcomes and appropriate expectations should be communicated. Conclusions: Thorough knowledge of the functional anatomy of the muscles involved in the standardized PREEMPT injection paradigm is critical to achieve the efficacy and safety observed in clinical trials. In addition, it is important to assess a patient's baseline condition to anticipate the risk for unwanted outcomes that may result from treatment.

Original languageEnglish (US)
Pages (from-to)766-777
Number of pages12
JournalHeadache
Volume57
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Migraine Disorders
Anatomy
Muscles
Injections
Research
Therapeutics
Neck Muscles
Preexisting Condition Coverage
Blood Vessels
Head
Clinical Trials
Safety

Keywords

  • chronic migraine
  • clinical
  • injection technique
  • onabotulinumtoxinA

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Insights into the Functional Anatomy Behind the PREEMPT Injection Paradigm : Guidance on Achieving Optimal Outcomes. / Blumenfeld, Andrew M.; Silberstein, Stephen D.; Dodick, David William; Aurora, Sheena K.; Brin, Mitchell F.; Binder, William J.

In: Headache, Vol. 57, No. 5, 01.05.2017, p. 766-777.

Research output: Contribution to journalArticle

Blumenfeld, Andrew M. ; Silberstein, Stephen D. ; Dodick, David William ; Aurora, Sheena K. ; Brin, Mitchell F. ; Binder, William J. / Insights into the Functional Anatomy Behind the PREEMPT Injection Paradigm : Guidance on Achieving Optimal Outcomes. In: Headache. 2017 ; Vol. 57, No. 5. pp. 766-777.
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