Insights from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Part I: Gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies

Leslee J. Shaw, C. Noel Bairey Merz, Carl J. Pepine, Steven E. Reis, Vera Bittner, Sheryl F. Kelsey, Marian Olson, B. Delia Johnson, Sunil Mankad, Barry L. Sharaf, William J. Rogers, Timothy R. Wessel, Christopher B. Arant, Gerald M. Pohost, Amir Lerman, Arshed A. Quyyumi, George Sopko

Research output: Contribution to journalArticle

482 Citations (Scopus)

Abstract

Despite a dramatic decline in mortality over the past three decades, coronary heart disease is the leading cause of death and disability in the U.S. Importantly, recent advances in the field of cardiovascular medicine have not led to significant declines in case fatality rates for women when compared to the dramatic declines realized for men. The current review highlights gender-specific issues in ischemic heart disease presentation, evaluation, and outcomes with a special focus on the results published from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. We will present recent evidence on traditional and novel risk markers (e.g., high sensitivity C-reactive protein) as well as gender-specific differences in symptoms and diagnostic approaches. An overview of currently available diagnostic test evidence (including exercise electrocardiography and stress echocardiography and single-photon emission computed tomographic imaging) in symptomatic women will be presented as well as data using innovative imaging techniques such as magnetic resonance subendocardial perfusion, and spectroscopic imaging will also be discussed.

Original languageEnglish (US)
JournalJournal of the American College of Cardiology
Volume47
Issue number3 SUPPL.
DOIs
StatePublished - Feb 7 2006

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National Heart, Lung, and Blood Institute (U.S.)
Symptom Assessment
Ischemia
Stress Echocardiography
Perfusion Imaging
Mortality
National Institutes of Health (U.S.)
Interpersonal Relations
Photons
Routine Diagnostic Tests
C-Reactive Protein
Myocardial Ischemia
Coronary Disease
Cause of Death
Electrocardiography
Magnetic Resonance Spectroscopy
Medicine
Exercise

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Insights from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Part I : Gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. / Shaw, Leslee J.; Bairey Merz, C. Noel; Pepine, Carl J.; Reis, Steven E.; Bittner, Vera; Kelsey, Sheryl F.; Olson, Marian; Johnson, B. Delia; Mankad, Sunil; Sharaf, Barry L.; Rogers, William J.; Wessel, Timothy R.; Arant, Christopher B.; Pohost, Gerald M.; Lerman, Amir; Quyyumi, Arshed A.; Sopko, George.

In: Journal of the American College of Cardiology, Vol. 47, No. 3 SUPPL., 07.02.2006.

Research output: Contribution to journalArticle

Shaw, LJ, Bairey Merz, CN, Pepine, CJ, Reis, SE, Bittner, V, Kelsey, SF, Olson, M, Johnson, BD, Mankad, S, Sharaf, BL, Rogers, WJ, Wessel, TR, Arant, CB, Pohost, GM, Lerman, A, Quyyumi, AA & Sopko, G 2006, 'Insights from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Part I: Gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies', Journal of the American College of Cardiology, vol. 47, no. 3 SUPPL.. https://doi.org/10.1016/j.jacc.2005.01.072
Shaw, Leslee J. ; Bairey Merz, C. Noel ; Pepine, Carl J. ; Reis, Steven E. ; Bittner, Vera ; Kelsey, Sheryl F. ; Olson, Marian ; Johnson, B. Delia ; Mankad, Sunil ; Sharaf, Barry L. ; Rogers, William J. ; Wessel, Timothy R. ; Arant, Christopher B. ; Pohost, Gerald M. ; Lerman, Amir ; Quyyumi, Arshed A. ; Sopko, George. / Insights from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Part I : Gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. In: Journal of the American College of Cardiology. 2006 ; Vol. 47, No. 3 SUPPL.
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