Insights from the gene expression profiling of multiple myeloma.

Jaime O. Claudio, Esther Masih-Khan, Alexander Keith Stewart

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Recent gene expression profiling using high throughput sequencing and microarray analysis of multiple myeloma has shed new light on this morphologically homogeneous yet clinically heterogeneous disease. The biology of the disease has been interrogated in studies, which reveal that patients have unique gene expression clusters that correlate with disease severity. These studies have also revealed that some myeloma cells have gene expression characteristics that resemble the molecular profile of late-stage B cells. Expression profiling can identify hallmark immunoglobulin translocations and other common structural genetic changes that impart prognostic significance. Molecular profiling has been demonstrated to be of value in pharmacogenomic studies predicting response to therapy and revealing novel therapeutic targets. These studies are providing insight into many previously unexplained features of this difficult disease.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalCurrent hematology reports
Volume3
Issue number1
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Gene Expression Profiling
Multiple Myeloma
Gene Expression
Microarray Analysis
Multigene Family
Immunoglobulins
B-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Insights from the gene expression profiling of multiple myeloma. / Claudio, Jaime O.; Masih-Khan, Esther; Stewart, Alexander Keith.

In: Current hematology reports, Vol. 3, No. 1, 01.2004, p. 67-73.

Research output: Contribution to journalArticle

Claudio, Jaime O. ; Masih-Khan, Esther ; Stewart, Alexander Keith. / Insights from the gene expression profiling of multiple myeloma. In: Current hematology reports. 2004 ; Vol. 3, No. 1. pp. 67-73.
@article{7c146a967a9e45d78975f2f860a7095f,
title = "Insights from the gene expression profiling of multiple myeloma.",
abstract = "Recent gene expression profiling using high throughput sequencing and microarray analysis of multiple myeloma has shed new light on this morphologically homogeneous yet clinically heterogeneous disease. The biology of the disease has been interrogated in studies, which reveal that patients have unique gene expression clusters that correlate with disease severity. These studies have also revealed that some myeloma cells have gene expression characteristics that resemble the molecular profile of late-stage B cells. Expression profiling can identify hallmark immunoglobulin translocations and other common structural genetic changes that impart prognostic significance. Molecular profiling has been demonstrated to be of value in pharmacogenomic studies predicting response to therapy and revealing novel therapeutic targets. These studies are providing insight into many previously unexplained features of this difficult disease.",
author = "Claudio, {Jaime O.} and Esther Masih-Khan and Stewart, {Alexander Keith}",
year = "2004",
month = "1",
language = "English (US)",
volume = "3",
pages = "67--73",
journal = "Current hematology reports",
issn = "1540-3408",
publisher = "Current Science, Inc.",
number = "1",

}

TY - JOUR

T1 - Insights from the gene expression profiling of multiple myeloma.

AU - Claudio, Jaime O.

AU - Masih-Khan, Esther

AU - Stewart, Alexander Keith

PY - 2004/1

Y1 - 2004/1

N2 - Recent gene expression profiling using high throughput sequencing and microarray analysis of multiple myeloma has shed new light on this morphologically homogeneous yet clinically heterogeneous disease. The biology of the disease has been interrogated in studies, which reveal that patients have unique gene expression clusters that correlate with disease severity. These studies have also revealed that some myeloma cells have gene expression characteristics that resemble the molecular profile of late-stage B cells. Expression profiling can identify hallmark immunoglobulin translocations and other common structural genetic changes that impart prognostic significance. Molecular profiling has been demonstrated to be of value in pharmacogenomic studies predicting response to therapy and revealing novel therapeutic targets. These studies are providing insight into many previously unexplained features of this difficult disease.

AB - Recent gene expression profiling using high throughput sequencing and microarray analysis of multiple myeloma has shed new light on this morphologically homogeneous yet clinically heterogeneous disease. The biology of the disease has been interrogated in studies, which reveal that patients have unique gene expression clusters that correlate with disease severity. These studies have also revealed that some myeloma cells have gene expression characteristics that resemble the molecular profile of late-stage B cells. Expression profiling can identify hallmark immunoglobulin translocations and other common structural genetic changes that impart prognostic significance. Molecular profiling has been demonstrated to be of value in pharmacogenomic studies predicting response to therapy and revealing novel therapeutic targets. These studies are providing insight into many previously unexplained features of this difficult disease.

UR - http://www.scopus.com/inward/record.url?scp=2442485949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442485949&partnerID=8YFLogxK

M3 - Article

C2 - 14695854

AN - SCOPUS:2442485949

VL - 3

SP - 67

EP - 73

JO - Current hematology reports

JF - Current hematology reports

SN - 1540-3408

IS - 1

ER -