Insight into regulatory factor targeting to transcriptionally active subnuclear sites

Gary S. Stein, André J. Van Wijnen, Janet L. Stein, Jane B. Lian, Amjad Javed, Sandra McNeil, Shirwin M. Pockwinse

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Mechanisms that coordinate the spatial organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture contribute to the sorting of regulatory information as well as the assembly and activity of sites within the nucleus that support gene expression. In this article we will present an overview of experimental approaches that provide insight into the trafficking of the hematopoietic and bone-specific AML/CBF family of regulatory factors to transcriptionally active subnuclear sites.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalExperimental Cell Research
Volume253
Issue number1
DOIs
StatePublished - Nov 25 1999

Keywords

  • AML/CBFα
  • Gene expression
  • Nuclear domains
  • Transcriptional control

ASJC Scopus subject areas

  • Cell Biology

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