@inbook{1cb583eb8fee493fa8b265340f6b0635,
title = "Insect acetylcholinesterase as a target for effective and environmentally safe insecticides",
abstract = "Insecticides are a cost-effective approach to managing disease-carrying, crop-destroying, and residential pest insects. However, current anticholinesterase insecticides are toxic to beneficial insects and vertebrates because they target the catalytic serine residue of acetylcholinesterase, a hydrolase vital to the regulation of acetylcholine in both invertebrates and vertebrates. Targeting this serine residue for more than 70 years has also contributed to current problems with insecticide resistance. This chapter presents data undergirding a mechanistically new insecticide concept that targets a cysteine residue unique in pest insect acetylcholinesterase to impart species-selective toxicity and a low propensity for resistance. These data are used to discuss how gainful deployment of the mechanism of irreversible inhibition of the acetylcholinesterase responsible for cholinergic functions in pest insects-but not in social bees and other higher social hymenopterans-may lead to cysteine-targeting anticholinesterases that are effective and environmentally safe in controlling pest insects while sparing economically important beneficial insects.",
keywords = "Acetylcholinesterase, Anticholinesterases, Cysteine-targeting insecticides, Insecticide resistance, Irreversible inhibitors, Neuroactive insecticides, Selective toxicity",
author = "Pang, {Yuan Ping}",
note = "Funding Information: Yuan-Ping Pang is in debt to (1) his co-workers and collaborators (Dengfeng Dou, Jewn Giew Park, Sandeep Rana, Sanjay K. Singh, Rajesh K. Mishra, Shaohua Wang, Lei Peng, Min Hong, Benjamin J. Madden, Haobo Jiang, Stephen Brimijoin, Gregory A. Polsinelli, Yang Gao, T. Leon Lassiter, David W. Ragsdale, Robert Suranyi, Ann M. Fallon, Kun Yan Zhu, Fredrik Ekstr{\"o}m, Bj{\"o}rn Andersson, Per Ola Andersson, and Duy H. Hua) for their collective contributions to the cysteine-targeting insecticide project at the Mayo Clinic; (2) Franklyn G. Prendergast for his encouragement and stimulating discussion of the cysteine-targeting insecticide concept; (3) Deirdre A. Herman for her constant new inputs and unwavering support for the cysteine-targeting insecticide project at the Mayo Clinic, and (4) funding from the US Army Research Office (W911NF-09-1-0095), the US Army Medical Research Material Command (W81XWH-04-2-0001 and W81XWH-08-1-0154), the Minnesota Partnership for Medical Genomics and Biotechnology, and Agriculture and Food Research Initiative Competitive Grant no. 2010-65105-20553 from the US Department of Agriculture National Institute of Food and Agriculture for developing a generic approach to irreversible inhibitors of pathogenic enzymes and cysteine-targeting insecticides to control crop damage. The author is grateful to editor Ephraim Cohen for his invitation to write this chapter. Corrections and comments from the editor and an anonymous reviewer are also greatly appreciated. ",
year = "2014",
doi = "10.1016/B978-0-12-417010-0.00006-9",
language = "English (US)",
series = "Advances in Insect Physiology",
publisher = "Academic Press Inc",
pages = "435--494",
booktitle = "Advances in Insect Physiology",
}