Innovative Therapeutics: Designer Natriuretic Peptides

Laura M.G. Meems, John C. Burnett

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Natriuretic peptides (NPs) are essential for the maintenance of volume homeostasis, and can be of myocardial, renal, and endothelial origin. Advances in peptide engineering have enabled the design of innovative designer NPs that go beyond native peptides in efficacy, specificity, and resistance to enzymatic degradation. Therefore, designer NPs provide an unparalleled opportunity for the treatment of cardiovascular disease. In this review, we report the conceptual framework of peptide engineering of the NPs that resulted in designer peptides for cardiovascular disease. We specifically provide an update on those currently in clinical trials for heart failure and hypertension.

Original languageEnglish (US)
Pages (from-to)557-567
Number of pages11
JournalJACC: Basic to Translational Science
Volume1
Issue number7
DOIs
StatePublished - 2016

Keywords

  • designer natriuretic peptide
  • drug development
  • heart failure
  • hypertension
  • natriuretic peptide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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