Innovative evolution of cancer gene and cellular therapies

P. Lam, G. Khan, R. Stripecke, K. M. Hui, N. Kasahara, K. W. Peng, B. A. Guinn

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

We provide an overview of the latest developments in cancer gene therapy - from the bench to early-stage clinical trials. We describe the most recent work of worldwide teams including experienced scientists and clinicians, reflecting the recent emergence of gene therapy from the 'Valley of Death'. treatment efficacy of clinical gene therapy has now been shown in a number of diseases including cancer and we are observing a renewed interest by big pharmaceutical and biotechnology companies most obviously demonstrated by Amgen's acquisition of Biovex for up to USD$1 billion. There is an opportunity to be cautiously hopeful regarding the future of gene therapy in the clinic and we review here some of the most recent progress in the field.

Original languageEnglish (US)
Pages (from-to)141-149
Number of pages9
JournalCancer Gene Therapy
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • cancer research
  • immunotherapy
  • stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

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    Lam, P., Khan, G., Stripecke, R., Hui, K. M., Kasahara, N., Peng, K. W., & Guinn, B. A. (2013). Innovative evolution of cancer gene and cellular therapies. Cancer Gene Therapy, 20(3), 141-149. https://doi.org/10.1038/cgt.2012.93