Innervation of the heart: An invisible grid within a black box

Suraj Kapa, Christopher V. DeSimone, Samuel J Asirvatham

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Autonomic control of cardiovascular function is mediated by a complex interplay between central, peripheral, and innate cardiac components. This interplay is what mediates the normal cardiovascular response to physiologic and pathologic stressors, including blood pressure, cardiac contractile function, and arrhythmias. However, in order to understand how modern therapies directly affecting autonomic function may be harnessed to treat various cardiovascular disease states requires an intimate understanding of anatomic and physiologic features of the innervation of the heart. Thus, in this review, we focus on defining features of the central, peripheral, and cardiac components of cardiac innervation, how each component may contribute to dysregulation of normal cardiac function in various disease states, and how modulation of these components may offer therapeutic options for these diseases.

Original languageEnglish (US)
JournalTrends in Cardiovascular Medicine
DOIs
StateAccepted/In press - 2015

Fingerprint

Cardiac Arrhythmias
Cardiovascular Diseases
Blood Pressure
Therapeutics

Keywords

  • Arrhythmias
  • Autonomic innervation
  • Cardiac
  • Cardiovascular system
  • Heart
  • Nervous system
  • Vascular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Innervation of the heart : An invisible grid within a black box. / Kapa, Suraj; DeSimone, Christopher V.; Asirvatham, Samuel J.

In: Trends in Cardiovascular Medicine, 2015.

Research output: Contribution to journalArticle

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