Inner perineurial cell vulnerability in ischemia

Timothy J. Benstead, Peter J Dyck, Virgilio Sangalang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The perineurium of peripheral nerve plays important roles in anatomical organization of fibers groups in endoneurial fluid homeostasis and in maintenance of tensile strength but little is known about the functional and structural alterations of the perineurium with injury. Large arteries of supply to lower limb of Sprague-Dawley rats were ligated to study the structural reactions of perineurium at 36 h and at 7 days after induction of ischemic injury. Lipid droplets were found to be an early reactive change to ischemia in multiple cell types including perineurial, endothelial and Schwann cells. In peripheral nerve levels showing early myelinated fiber injury the inner perineurial sheath was widened and was undergoing degeneration. The inner layers of perineurial cells showed swelling, organelle disruption and membrane dissolution while outer layers remained intact. Inner perineurial cell degeneration is a prominent early feature of ischemic injury and may be an important mechanism of altered endoneurial homeostasis, fiber function and structure.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalBrain Research
Volume489
Issue number1
DOIs
StatePublished - Jun 5 1989

Fingerprint

Peripheral Nerves
Ischemia
Wounds and Injuries
Homeostasis
Tensile Strength
Schwann Cells
Organelles
Sprague Dawley Rats
Lower Extremity
Endothelial Cells
Arteries
Maintenance
Membranes

Keywords

  • Cell death
  • Ischemic neuropathy
  • Lipid droplet
  • Morphometry
  • Perineurium
  • Peripheral nerve

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Inner perineurial cell vulnerability in ischemia. / Benstead, Timothy J.; Dyck, Peter J; Sangalang, Virgilio.

In: Brain Research, Vol. 489, No. 1, 05.06.1989, p. 177-181.

Research output: Contribution to journalArticle

Benstead, Timothy J. ; Dyck, Peter J ; Sangalang, Virgilio. / Inner perineurial cell vulnerability in ischemia. In: Brain Research. 1989 ; Vol. 489, No. 1. pp. 177-181.
@article{7dd95f4cf9564de3bb375e59d56c8b9e,
title = "Inner perineurial cell vulnerability in ischemia",
abstract = "The perineurium of peripheral nerve plays important roles in anatomical organization of fibers groups in endoneurial fluid homeostasis and in maintenance of tensile strength but little is known about the functional and structural alterations of the perineurium with injury. Large arteries of supply to lower limb of Sprague-Dawley rats were ligated to study the structural reactions of perineurium at 36 h and at 7 days after induction of ischemic injury. Lipid droplets were found to be an early reactive change to ischemia in multiple cell types including perineurial, endothelial and Schwann cells. In peripheral nerve levels showing early myelinated fiber injury the inner perineurial sheath was widened and was undergoing degeneration. The inner layers of perineurial cells showed swelling, organelle disruption and membrane dissolution while outer layers remained intact. Inner perineurial cell degeneration is a prominent early feature of ischemic injury and may be an important mechanism of altered endoneurial homeostasis, fiber function and structure.",
keywords = "Cell death, Ischemic neuropathy, Lipid droplet, Morphometry, Perineurium, Peripheral nerve",
author = "Benstead, {Timothy J.} and Dyck, {Peter J} and Virgilio Sangalang",
year = "1989",
month = "6",
day = "5",
doi = "10.1016/0006-8993(89)90021-8",
language = "English (US)",
volume = "489",
pages = "177--181",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Inner perineurial cell vulnerability in ischemia

AU - Benstead, Timothy J.

AU - Dyck, Peter J

AU - Sangalang, Virgilio

PY - 1989/6/5

Y1 - 1989/6/5

N2 - The perineurium of peripheral nerve plays important roles in anatomical organization of fibers groups in endoneurial fluid homeostasis and in maintenance of tensile strength but little is known about the functional and structural alterations of the perineurium with injury. Large arteries of supply to lower limb of Sprague-Dawley rats were ligated to study the structural reactions of perineurium at 36 h and at 7 days after induction of ischemic injury. Lipid droplets were found to be an early reactive change to ischemia in multiple cell types including perineurial, endothelial and Schwann cells. In peripheral nerve levels showing early myelinated fiber injury the inner perineurial sheath was widened and was undergoing degeneration. The inner layers of perineurial cells showed swelling, organelle disruption and membrane dissolution while outer layers remained intact. Inner perineurial cell degeneration is a prominent early feature of ischemic injury and may be an important mechanism of altered endoneurial homeostasis, fiber function and structure.

AB - The perineurium of peripheral nerve plays important roles in anatomical organization of fibers groups in endoneurial fluid homeostasis and in maintenance of tensile strength but little is known about the functional and structural alterations of the perineurium with injury. Large arteries of supply to lower limb of Sprague-Dawley rats were ligated to study the structural reactions of perineurium at 36 h and at 7 days after induction of ischemic injury. Lipid droplets were found to be an early reactive change to ischemia in multiple cell types including perineurial, endothelial and Schwann cells. In peripheral nerve levels showing early myelinated fiber injury the inner perineurial sheath was widened and was undergoing degeneration. The inner layers of perineurial cells showed swelling, organelle disruption and membrane dissolution while outer layers remained intact. Inner perineurial cell degeneration is a prominent early feature of ischemic injury and may be an important mechanism of altered endoneurial homeostasis, fiber function and structure.

KW - Cell death

KW - Ischemic neuropathy

KW - Lipid droplet

KW - Morphometry

KW - Perineurium

KW - Peripheral nerve

UR - http://www.scopus.com/inward/record.url?scp=0024322654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024322654&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(89)90021-8

DO - 10.1016/0006-8993(89)90021-8

M3 - Article

C2 - 2743147

AN - SCOPUS:0024322654

VL - 489

SP - 177

EP - 181

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -