Injectable Flexible Subcutaneous Electrode Array Technology for Electrocardiogram Monitoring Device

Jihye Bong, Omar Yasin, Vaibhav R. Vaidya, Jeongpil Park, Zachi I. Attia, Deepak Padmanabhan, Sang June Cho, Roshini Asirvatham, Noah Schneider, Juhwan Lee, Eun Mee Kim, Paul A. Friedman, Zhenqiang Ma

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Implantable cardiac monitors have undergone considerable miniaturization. However, they continue to be associated with complications such as infection, bleeding/bruising, and device extrusion or migration. In this paper, we demonstrate the feasibility of using a small, flexible, injectable, subcutaneous microelectrode-based device to record electrocardiograms (ECGs). We describe the fabrication process and demonstrate the ease of insertion of the injectable ECG device in vivo swine model. We also demonstrate our device's high-density channel microelectrode array's ability to detect the P, R, and T waves. The amplitude of these waves showed excellent correlation with distance of the bipolar electrodes used to detect them. Given the success of our initial studies, this device has the potential to improve the safety profile of implantable cardiac monitors and simplify the implantation procedure to allow for placement in a primary care setting.

Original languageEnglish (US)
Pages (from-to)2652-2658
Number of pages7
JournalACS Biomaterials Science and Engineering
Volume6
Issue number5
DOIs
StatePublished - May 11 2020

Keywords

  • flexible electronics
  • injectable device
  • medical implantable monitors
  • subcutaneous biosensor

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Bong, J., Yasin, O., Vaidya, V. R., Park, J., Attia, Z. I., Padmanabhan, D., Cho, S. J., Asirvatham, R., Schneider, N., Lee, J., Kim, E. M., Friedman, P. A., & Ma, Z. (2020). Injectable Flexible Subcutaneous Electrode Array Technology for Electrocardiogram Monitoring Device. ACS Biomaterials Science and Engineering, 6(5), 2652-2658. https://doi.org/10.1021/acsbiomaterials.9b01102