Initiation of motility in canine ileum by short chain fatty acids and inhibition by pharmacological agents

Patrick Sequeira Kamath, S. F. Phillips

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We have previously shown that short chain fatty acids (SCFA) stimulate motility in the canine ileum. Concentrations of SCFA in the ileum are normally low but would be expected to increase after coloileal reflux; thus, this phenomenon could have pathophysiological relevance. The present studies were designed to seek pharmacological means by which this response could be blocked. Four dogs were prepared with isolated, ileocolonic fistulae into which physiological concentrations of SCFA could be instilled so as to stimulate ileal motility. Pretreatment of the ileum with topical lidocaine abolished the response to luminal SCFA but general anaesthesia did not. Indomethacin stimulated ileal motility and prostacyclin abolished the ileal response to SCFA. Naloxone and a calcium channel blocker also negated the response to SCFA; blockage of muscarinic, adrenergic and 5-HT receptors did not. We conclude that the motor response to SCFA is probably a local neural reflex which is sensitive to local anaesthetics, opiates and the prostanoids.

Original languageEnglish (US)
Pages (from-to)941-948
Number of pages8
JournalGut
Volume29
Issue number7
StatePublished - 1988

Fingerprint

Volatile Fatty Acids
Ileum
Canidae
Pharmacology
Opiate Alkaloids
Serotonin Receptors
Calcium Channel Blockers
Epoprostenol
Naloxone
Lidocaine
Local Anesthetics
Inhibition (Psychology)
Indomethacin
Adrenergic Agents
General Anesthesia
Cholinergic Agents
Fistula
Prostaglandins
Reflex
Dogs

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Initiation of motility in canine ileum by short chain fatty acids and inhibition by pharmacological agents. / Kamath, Patrick Sequeira; Phillips, S. F.

In: Gut, Vol. 29, No. 7, 1988, p. 941-948.

Research output: Contribution to journalArticle

@article{9ceef1f691dc45498233462bae22c5e6,
title = "Initiation of motility in canine ileum by short chain fatty acids and inhibition by pharmacological agents",
abstract = "We have previously shown that short chain fatty acids (SCFA) stimulate motility in the canine ileum. Concentrations of SCFA in the ileum are normally low but would be expected to increase after coloileal reflux; thus, this phenomenon could have pathophysiological relevance. The present studies were designed to seek pharmacological means by which this response could be blocked. Four dogs were prepared with isolated, ileocolonic fistulae into which physiological concentrations of SCFA could be instilled so as to stimulate ileal motility. Pretreatment of the ileum with topical lidocaine abolished the response to luminal SCFA but general anaesthesia did not. Indomethacin stimulated ileal motility and prostacyclin abolished the ileal response to SCFA. Naloxone and a calcium channel blocker also negated the response to SCFA; blockage of muscarinic, adrenergic and 5-HT receptors did not. We conclude that the motor response to SCFA is probably a local neural reflex which is sensitive to local anaesthetics, opiates and the prostanoids.",
author = "Kamath, {Patrick Sequeira} and Phillips, {S. F.}",
year = "1988",
language = "English (US)",
volume = "29",
pages = "941--948",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "7",

}

TY - JOUR

T1 - Initiation of motility in canine ileum by short chain fatty acids and inhibition by pharmacological agents

AU - Kamath, Patrick Sequeira

AU - Phillips, S. F.

PY - 1988

Y1 - 1988

N2 - We have previously shown that short chain fatty acids (SCFA) stimulate motility in the canine ileum. Concentrations of SCFA in the ileum are normally low but would be expected to increase after coloileal reflux; thus, this phenomenon could have pathophysiological relevance. The present studies were designed to seek pharmacological means by which this response could be blocked. Four dogs were prepared with isolated, ileocolonic fistulae into which physiological concentrations of SCFA could be instilled so as to stimulate ileal motility. Pretreatment of the ileum with topical lidocaine abolished the response to luminal SCFA but general anaesthesia did not. Indomethacin stimulated ileal motility and prostacyclin abolished the ileal response to SCFA. Naloxone and a calcium channel blocker also negated the response to SCFA; blockage of muscarinic, adrenergic and 5-HT receptors did not. We conclude that the motor response to SCFA is probably a local neural reflex which is sensitive to local anaesthetics, opiates and the prostanoids.

AB - We have previously shown that short chain fatty acids (SCFA) stimulate motility in the canine ileum. Concentrations of SCFA in the ileum are normally low but would be expected to increase after coloileal reflux; thus, this phenomenon could have pathophysiological relevance. The present studies were designed to seek pharmacological means by which this response could be blocked. Four dogs were prepared with isolated, ileocolonic fistulae into which physiological concentrations of SCFA could be instilled so as to stimulate ileal motility. Pretreatment of the ileum with topical lidocaine abolished the response to luminal SCFA but general anaesthesia did not. Indomethacin stimulated ileal motility and prostacyclin abolished the ileal response to SCFA. Naloxone and a calcium channel blocker also negated the response to SCFA; blockage of muscarinic, adrenergic and 5-HT receptors did not. We conclude that the motor response to SCFA is probably a local neural reflex which is sensitive to local anaesthetics, opiates and the prostanoids.

UR - http://www.scopus.com/inward/record.url?scp=0023706975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023706975&partnerID=8YFLogxK

M3 - Article

C2 - 3396966

AN - SCOPUS:0023706975

VL - 29

SP - 941

EP - 948

JO - Gut

JF - Gut

SN - 0017-5749

IS - 7

ER -