Initial results of QuantiFERON-TB Gold testing in patients with uveitis

S. Itty, S. J. Bakri, Jose S Pulido, D. C. Herman, L. J. Faia, G. T. Tufty, S. R. Bennett, N. S. Falk

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose To describe the use of the second-generation QuantiFERON-TB Gold (QFT-G) test in a series of patients in an ophthalmic practice.MethodsThe charts of all patients who had QFT-G tests ordered by Mayo Clinic ophthalmologists in the past 3 years were reviewed.ResultsA total of 27 QFT-G tests were ordered. Thirteen (48%) tests were negative, six (22%) were indeterminate, two (7%) tests were re-ordered after a lab accident or an improper cancellation, four (15%) were positive and represented infection, and two (7%) were positive but negative when re-tested. Of the four truly positive cases, three were treated for tuberculosis (TB): one had tuberculous iritis, one had retinal vasculitis and haemorrhage, and one had asymptomatic TB but was on immunosuppressive therapy. The fourth patient had previously been treated for latent infection. ConclusionsIn a series of selected patients with uveitis, the QFT-G test was able to detect TB infection in 15% of the patients, though it does not differentiate between active and latent TB infection. QFT-G should be considered in place of purified protein derivative testing in those with uveitis that have had prior BCG vaccination and in immunocompromised patients. Patients with a positive QFT-G, but who have little risk for TB infection and a negative systemic work-up, should be re-tested.

Original languageEnglish (US)
Pages (from-to)904-909
Number of pages6
JournalEye
Volume23
Issue number4
DOIs
StatePublished - Apr 2009

Fingerprint

Uveitis
Gold
Tuberculosis
Infection
Retinal Vasculitis
Iritis
Retinal Hemorrhage
Latent Tuberculosis
Immunocompromised Host
Immunosuppressive Agents
Mycobacterium bovis
Accidents
Vaccination
Proteins

Keywords

  • Inflammation
  • QuantiFERON
  • Reversion
  • Tuberculosis
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Itty, S., Bakri, S. J., Pulido, J. S., Herman, D. C., Faia, L. J., Tufty, G. T., ... Falk, N. S. (2009). Initial results of QuantiFERON-TB Gold testing in patients with uveitis. Eye, 23(4), 904-909. https://doi.org/10.1038/eye.2008.115

Initial results of QuantiFERON-TB Gold testing in patients with uveitis. / Itty, S.; Bakri, S. J.; Pulido, Jose S; Herman, D. C.; Faia, L. J.; Tufty, G. T.; Bennett, S. R.; Falk, N. S.

In: Eye, Vol. 23, No. 4, 04.2009, p. 904-909.

Research output: Contribution to journalArticle

Itty, S, Bakri, SJ, Pulido, JS, Herman, DC, Faia, LJ, Tufty, GT, Bennett, SR & Falk, NS 2009, 'Initial results of QuantiFERON-TB Gold testing in patients with uveitis', Eye, vol. 23, no. 4, pp. 904-909. https://doi.org/10.1038/eye.2008.115
Itty S, Bakri SJ, Pulido JS, Herman DC, Faia LJ, Tufty GT et al. Initial results of QuantiFERON-TB Gold testing in patients with uveitis. Eye. 2009 Apr;23(4):904-909. https://doi.org/10.1038/eye.2008.115
Itty, S. ; Bakri, S. J. ; Pulido, Jose S ; Herman, D. C. ; Faia, L. J. ; Tufty, G. T. ; Bennett, S. R. ; Falk, N. S. / Initial results of QuantiFERON-TB Gold testing in patients with uveitis. In: Eye. 2009 ; Vol. 23, No. 4. pp. 904-909.
@article{a21ef2922030441aa57292f60cbf6e30,
title = "Initial results of QuantiFERON-TB Gold testing in patients with uveitis",
abstract = "Purpose To describe the use of the second-generation QuantiFERON-TB Gold (QFT-G) test in a series of patients in an ophthalmic practice.MethodsThe charts of all patients who had QFT-G tests ordered by Mayo Clinic ophthalmologists in the past 3 years were reviewed.ResultsA total of 27 QFT-G tests were ordered. Thirteen (48{\%}) tests were negative, six (22{\%}) were indeterminate, two (7{\%}) tests were re-ordered after a lab accident or an improper cancellation, four (15{\%}) were positive and represented infection, and two (7{\%}) were positive but negative when re-tested. Of the four truly positive cases, three were treated for tuberculosis (TB): one had tuberculous iritis, one had retinal vasculitis and haemorrhage, and one had asymptomatic TB but was on immunosuppressive therapy. The fourth patient had previously been treated for latent infection. ConclusionsIn a series of selected patients with uveitis, the QFT-G test was able to detect TB infection in 15{\%} of the patients, though it does not differentiate between active and latent TB infection. QFT-G should be considered in place of purified protein derivative testing in those with uveitis that have had prior BCG vaccination and in immunocompromised patients. Patients with a positive QFT-G, but who have little risk for TB infection and a negative systemic work-up, should be re-tested.",
keywords = "Inflammation, QuantiFERON, Reversion, Tuberculosis, Uveitis",
author = "S. Itty and Bakri, {S. J.} and Pulido, {Jose S} and Herman, {D. C.} and Faia, {L. J.} and Tufty, {G. T.} and Bennett, {S. R.} and Falk, {N. S.}",
year = "2009",
month = "4",
doi = "10.1038/eye.2008.115",
language = "English (US)",
volume = "23",
pages = "904--909",
journal = "Eye (Basingstoke)",
issn = "0950-222X",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Initial results of QuantiFERON-TB Gold testing in patients with uveitis

AU - Itty, S.

AU - Bakri, S. J.

AU - Pulido, Jose S

AU - Herman, D. C.

AU - Faia, L. J.

AU - Tufty, G. T.

AU - Bennett, S. R.

AU - Falk, N. S.

PY - 2009/4

Y1 - 2009/4

N2 - Purpose To describe the use of the second-generation QuantiFERON-TB Gold (QFT-G) test in a series of patients in an ophthalmic practice.MethodsThe charts of all patients who had QFT-G tests ordered by Mayo Clinic ophthalmologists in the past 3 years were reviewed.ResultsA total of 27 QFT-G tests were ordered. Thirteen (48%) tests were negative, six (22%) were indeterminate, two (7%) tests were re-ordered after a lab accident or an improper cancellation, four (15%) were positive and represented infection, and two (7%) were positive but negative when re-tested. Of the four truly positive cases, three were treated for tuberculosis (TB): one had tuberculous iritis, one had retinal vasculitis and haemorrhage, and one had asymptomatic TB but was on immunosuppressive therapy. The fourth patient had previously been treated for latent infection. ConclusionsIn a series of selected patients with uveitis, the QFT-G test was able to detect TB infection in 15% of the patients, though it does not differentiate between active and latent TB infection. QFT-G should be considered in place of purified protein derivative testing in those with uveitis that have had prior BCG vaccination and in immunocompromised patients. Patients with a positive QFT-G, but who have little risk for TB infection and a negative systemic work-up, should be re-tested.

AB - Purpose To describe the use of the second-generation QuantiFERON-TB Gold (QFT-G) test in a series of patients in an ophthalmic practice.MethodsThe charts of all patients who had QFT-G tests ordered by Mayo Clinic ophthalmologists in the past 3 years were reviewed.ResultsA total of 27 QFT-G tests were ordered. Thirteen (48%) tests were negative, six (22%) were indeterminate, two (7%) tests were re-ordered after a lab accident or an improper cancellation, four (15%) were positive and represented infection, and two (7%) were positive but negative when re-tested. Of the four truly positive cases, three were treated for tuberculosis (TB): one had tuberculous iritis, one had retinal vasculitis and haemorrhage, and one had asymptomatic TB but was on immunosuppressive therapy. The fourth patient had previously been treated for latent infection. ConclusionsIn a series of selected patients with uveitis, the QFT-G test was able to detect TB infection in 15% of the patients, though it does not differentiate between active and latent TB infection. QFT-G should be considered in place of purified protein derivative testing in those with uveitis that have had prior BCG vaccination and in immunocompromised patients. Patients with a positive QFT-G, but who have little risk for TB infection and a negative systemic work-up, should be re-tested.

KW - Inflammation

KW - QuantiFERON

KW - Reversion

KW - Tuberculosis

KW - Uveitis

UR - http://www.scopus.com/inward/record.url?scp=65349165785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65349165785&partnerID=8YFLogxK

U2 - 10.1038/eye.2008.115

DO - 10.1038/eye.2008.115

M3 - Article

VL - 23

SP - 904

EP - 909

JO - Eye (Basingstoke)

JF - Eye (Basingstoke)

SN - 0950-222X

IS - 4

ER -