Initial results from a prototype whole-body photon-counting computed tomography system

Z. Yu, Shuai Leng, S. M. Jorgensen, Z. Li, R. Gutjahr, B. Chen, X. Duan, A. F. Halaweish, Lifeng Yu, E. L. Ritman, Cynthia H McCollough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

36 Scopus citations

Abstract

X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9412
ISBN (Print)9781628415025
DOIs
StatePublished - 2015
EventMedical Imaging 2015: Physics of Medical Imaging - Orlando, United States
Duration: Feb 22 2015Feb 25 2015

Other

OtherMedical Imaging 2015: Physics of Medical Imaging
CountryUnited States
CityOrlando
Period2/22/152/25/15

Keywords

  • Photon-counting CT
  • Research prototype
  • System evaluation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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    Yu, Z., Leng, S., Jorgensen, S. M., Li, Z., Gutjahr, R., Chen, B., Duan, X., Halaweish, A. F., Yu, L., Ritman, E. L., & McCollough, C. H. (2015). Initial results from a prototype whole-body photon-counting computed tomography system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9412). [94120W] SPIE. https://doi.org/10.1117/12.2082739