Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee, Joo Ho Shin, Jackalina Vankampen, Leonard Petrucelli, Andrew B. West, Han Seok Ko, Yun Il Lee, Kathleen A. Maguire-Zeiss, William J. Bowers, Howard J. Federoff, Valina L. Dawson, Ted M. Dawson

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)998-1000
Number of pages3
JournalNature Medicine
Volume16
Issue number9
DOIs
StatePublished - Sep 2010

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Leucine
Parkinson Disease
Phosphotransferases
Nerve Degeneration
Neurons
Mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lee, B. D., Shin, J. H., Vankampen, J., Petrucelli, L., West, A. B., Ko, H. S., ... Dawson, T. M. (2010). Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine, 16(9), 998-1000. https://doi.org/10.1038/nm.2199

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. / Lee, Byoung Dae; Shin, Joo Ho; Vankampen, Jackalina; Petrucelli, Leonard; West, Andrew B.; Ko, Han Seok; Lee, Yun Il; Maguire-Zeiss, Kathleen A.; Bowers, William J.; Federoff, Howard J.; Dawson, Valina L.; Dawson, Ted M.

In: Nature Medicine, Vol. 16, No. 9, 09.2010, p. 998-1000.

Research output: Contribution to journalArticle

Lee, BD, Shin, JH, Vankampen, J, Petrucelli, L, West, AB, Ko, HS, Lee, YI, Maguire-Zeiss, KA, Bowers, WJ, Federoff, HJ, Dawson, VL & Dawson, TM 2010, 'Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease', Nature Medicine, vol. 16, no. 9, pp. 998-1000. https://doi.org/10.1038/nm.2199
Lee, Byoung Dae ; Shin, Joo Ho ; Vankampen, Jackalina ; Petrucelli, Leonard ; West, Andrew B. ; Ko, Han Seok ; Lee, Yun Il ; Maguire-Zeiss, Kathleen A. ; Bowers, William J. ; Federoff, Howard J. ; Dawson, Valina L. ; Dawson, Ted M. / Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. In: Nature Medicine. 2010 ; Vol. 16, No. 9. pp. 998-1000.
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