Abstract
Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.
Original language | English (US) |
---|---|
Pages (from-to) | 998-1000 |
Number of pages | 3 |
Journal | Nature Medicine |
Volume | 16 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2010 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)