Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee; Joo Ho Shin; Jackalina Vankampen; Leonard Petrucelli; Andrew B. West; Han Seok Ko; Yun Il Lee; Kathleen A. Maguire-Zeiss; William J. Bowers; Howard J. Federoff; Valina L. Dawson; Ted M. Dawson

doi:10.1038/nm.2199

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee, Joo Ho Shin, Jackalina Vankampen, Leonard Petrucelli, Andrew B. West, Han Seok Ko, Yun Il Lee, Kathleen A. Maguire-Zeiss, William J. Bowers, Howard J. Federoff, Valina L. Dawson, Ted M. Dawson

Neuroscience

Research output: Contribution to journal › Article

251 Scopus citations

Abstract

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.

Original language	English (US)
Pages (from-to)	998-1000
Number of pages	3
Journal	Nature Medicine
Volume	16
Issue number	9
DOIs	https://doi.org/10.1038/nm.2199
State	Published - Sep 1 2010

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ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lee, B. D., Shin, J. H., Vankampen, J., Petrucelli, L., West, A. B., Ko, H. S., Lee, Y. I., Maguire-Zeiss, K. A., Bowers, W. J., Federoff, H. J., Dawson, V. L., & Dawson, T. M. (2010). Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine, 16(9), 998-1000. https://doi.org/10.1038/nm.2199

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. / Lee, Byoung Dae; Shin, Joo Ho; Vankampen, Jackalina; Petrucelli, Leonard; West, Andrew B.; Ko, Han Seok; Lee, Yun Il; Maguire-Zeiss, Kathleen A.; Bowers, William J.; Federoff, Howard J.; Dawson, Valina L.; Dawson, Ted M.

In: Nature Medicine, Vol. 16, No. 9, 01.09.2010, p. 998-1000.

Research output: Contribution to journal › Article

Lee, Byoung Dae ; Shin, Joo Ho ; Vankampen, Jackalina ; Petrucelli, Leonard ; West, Andrew B. ; Ko, Han Seok ; Lee, Yun Il ; Maguire-Zeiss, Kathleen A. ; Bowers, William J. ; Federoff, Howard J. ; Dawson, Valina L. ; Dawson, Ted M. / Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. In: Nature Medicine. 2010 ; Vol. 16, No. 9. pp. 998-1000.

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