Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee; Joo Ho Shin; Jackalina Vankampen; Leonard Petrucelli; Andrew B. West; Han Seok Ko; Yun Il Lee; Kathleen A. Maguire-Zeiss; William J. Bowers; Howard J. Federoff; Valina L. Dawson; Ted M. Dawson

doi:10.1038/nm.2199

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee, Joo Ho Shin, Jackalina Vankampen, Leonard Petrucelli, Andrew B. West, Han Seok Ko, Yun Il Lee, Kathleen A. Maguire-Zeiss, William J. Bowers, Howard J. Federoff, Valina L. Dawson, Ted M. Dawson

Neuroscience

Research output: Contribution to journal › Article › peer-review

261 Scopus citations

Abstract

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.

Original language	English (US)
Pages (from-to)	998-1000
Number of pages	3
Journal	Nature Medicine
Volume	16
Issue number	9
DOIs	https://doi.org/10.1038/nm.2199
State	Published - Sep 2010

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. / Lee, Byoung Dae; Shin, Joo Ho; Vankampen, Jackalina; Petrucelli, Leonard; West, Andrew B.; Ko, Han Seok; Lee, Yun Il; Maguire-Zeiss, Kathleen A.; Bowers, William J.; Federoff, Howard J.; Dawson, Valina L.; Dawson, Ted M.

In: Nature Medicine, Vol. 16, No. 9, 09.2010, p. 998-1000.

Research output: Contribution to journal › Article › peer-review

Lee, Byoung Dae ; Shin, Joo Ho ; Vankampen, Jackalina ; Petrucelli, Leonard ; West, Andrew B. ; Ko, Han Seok ; Lee, Yun Il ; Maguire-Zeiss, Kathleen A. ; Bowers, William J. ; Federoff, Howard J. ; Dawson, Valina L. ; Dawson, Ted M. / Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. In: Nature Medicine. 2010 ; Vol. 16, No. 9. pp. 998-1000.

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abstract = "Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.",

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