Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2

Resham Bhattacharya, Sucharita Senbanerjee, Zhiyong Lin, Samy Mir, Anne Hamik, Ping Wang, Priyabrata Mukherjee, Debabrata Mukhopadhyay, Mukesh K. Jain

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

The Kruppel-like factor KLF2 was recently identified as a novel regulator of endothelial pro-inflammatory and pro-thrombotic function. Here it is shown that over-expression of KLF2 potently inhibits vascular permeability factor/vascular endothelial growth factor (VEGF-A)-mediated angiogenesis and tissue edema in the nude ear mouse model of angiogenesis. In vitro, KLF2 expression retards VEGF-mediated calcium flux, proliferation and induction of pro-inflammatory factors in endothelial cells. This effect is due to a potent inhibition of VEGFR2/KDR expression and promoter activity. These observations identify KLF2 as a regulator of VEGFR2/KDR and provide a foundation for novel approaches to regulate angiogenesis.

Original languageEnglish (US)
Pages (from-to)28848-28851
Number of pages4
JournalJournal of Biological Chemistry
Volume280
Issue number32
DOIs
StatePublished - Aug 12 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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