Abstract
Employing a murine model of multiple sclerosis which utilizes intracraniai injection of Theiier's virus murine encephalomyelitis (TMEV) Into SJL/J mice, we tested the potential role of tumor necrosis factor alpha (TNF-a) In ameliorating CNS demyeiination. Infection with TMEV caused early grey matter Inflammation (7 days post-Infection) in the brain and spinal cord followed by chronic demyeiination (35 days post-infection) in the spinal cord. Administration of recombinant human or mouse TNF-a starting 12 h prior to infection and then three times weekly had minimal effect on development of grey matter Inflammation in the spinal cord. In contrast, TNF-a dramatically reduced demyeiination present In spinal cord on days 14 and 35 after TMEV infection (P < 0.01) when compared to controls. CNS virus tlters of TMEV were not modified by TNF-a administration as measured on days 7, 14, and 35 following infection. In vivo administration of TNF-a inhibits TMEV-induced demyeiination in susceptible SJL/J mice without affecting virus replication In the CNS.
Original language | English (US) |
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Pages (from-to) | 909-913 |
Number of pages | 5 |
Journal | International Immunology |
Volume | 2 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1990 |
Keywords
- Central nervous system
- Multiple sclerosis
- Myelin
- Oligodendrocyte
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology