Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha

C. V. Paya, P. J. Leibson, A. K. Patick, M. Rodriguez

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Employing a murine model of multiple sclerosis which utilizes intracranial injection of Theiler's virus murine encephalomyelitis (TMEV) into SJL/J mice, we tested the potential role of tumor necrosis factor alpha (TNF-α) in ameliorating CNS demyelination. Infection with TMEV caused early grey matter inflammation (7 days post-infection) in the brain and spinal cord followed by chronic demyelination (35 days post-infection) in the spinal cord. Administration of recombinant human or mouse TNF-α starting 12 h prior to infection and then three times weekly had minimal effect on development of grey matter inflammation in the spinal cord. In contrast, TNF-α dramatically reduced demyelination present in spinal cord on days 14 and 35 after TMEV infection (P < 0.01) when compared to controls. CNS virus titers of TMEV were not modified by TNF-α administration as measured on days 7, 14, and 35 following infection. In vivo administration of TNF-α inhibits TMEV-induced demyelination in susceptible SJL/J mic without affecting virus replication in the CNS.

Original languageEnglish (US)
Pages (from-to)909-913
Number of pages5
JournalInternational Immunology
Volume2
Issue number9
StatePublished - 1990

Fingerprint

Theilovirus
Tumor Necrosis Factor
Demyelinating Diseases
Viruses
Virus
Infection
Tumor Necrosis Factor-alpha
Spinal Cord
Inflammation
Mouse
Myelitis
Multiple Sclerosis
Virus Replication
Brain
Viral Load
Replication
Tumor necrosis factor-α
Injection
Injections

Keywords

  • Central nervous system
  • Multiple sclerosis
  • Myelin
  • Oligodendrocyte

ASJC Scopus subject areas

  • Immunology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Transplantation

Cite this

Paya, C. V., Leibson, P. J., Patick, A. K., & Rodriguez, M. (1990). Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha. International Immunology, 2(9), 909-913.

Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha. / Paya, C. V.; Leibson, P. J.; Patick, A. K.; Rodriguez, M.

In: International Immunology, Vol. 2, No. 9, 1990, p. 909-913.

Research output: Contribution to journalArticle

Paya, CV, Leibson, PJ, Patick, AK & Rodriguez, M 1990, 'Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha', International Immunology, vol. 2, no. 9, pp. 909-913.
Paya, C. V. ; Leibson, P. J. ; Patick, A. K. ; Rodriguez, M. / Inhibition of Theiler's virus-induced demyelination in vivo by tumor necrosis factor alpha. In: International Immunology. 1990 ; Vol. 2, No. 9. pp. 909-913.
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