Inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia

Qiang Cai, Stephen F. Hodgson, Pai C. Kao, Vanda A. Lennon, George G. Klee, Alan R. Zinsmiester, Rajiv Kumar

Research output: Contribution to journalArticlepeer-review

271 Scopus citations

Abstract

In tumor-induced osteomalacia, a rare syndrome characterized by hypophosphatemia, hyperphosphaturia, low plasma 1,25-dihydroxyvitamin D concentrations, and osteomalacia,15 all biochemical and pathological abnormalities disappear when the tumor is removed. Tumors associated with this syndrome are thought to secrete a substance that inhibits the renal tubular reabsorption of phosphate,15 but whether this factor interacts directly with renal tubular cells is not known. We investigated the ability of medium in which sclerosing hemangioma cells from a patient with oncogenic osteomalacia were cultured to alter sodium-dependent phosphate transport in opossum-kidney epithelial cells. We found that the medium inhibited phosphate transport, without increasing.

Original languageEnglish (US)
Pages (from-to)1645-1649
Number of pages5
JournalNew England Journal of Medicine
Volume330
Issue number23
DOIs
StatePublished - Jun 9 1994

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia'. Together they form a unique fingerprint.

Cite this