TY - JOUR
T1 - Inhibition of phorbol ester-induced human epidermal ornithine decarboxylase activity by oral compounds
T2 - A possible role in human chemoprevention studies
AU - Loprinzi, C. L.
AU - Verma, A. K.
AU - Boutwell, R. K.
AU - Carbone, P. P.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - Extensive animal data have suggested that, in some systems, the induction of ornithine decarboxylase (ODC) is an essential, although not sufficient, aspect of tumor promotion and that compounds that inhibit ODC can inhibit tumor formation. Using fasting human volunteers, we report that human epidermal and dermal ODC are consistently induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in a manner similar to that seen in mouse skin. There is a marked intersubject variation in TPA-induced epidermal ODC activity levels. Orally administered compounds significantly inhibited TPA-caused human epidermal ODC induction. These data may be useful in the furthest development of drugs, doses, and dose schedules for use in human cancer chemoprevention studies.
AB - Extensive animal data have suggested that, in some systems, the induction of ornithine decarboxylase (ODC) is an essential, although not sufficient, aspect of tumor promotion and that compounds that inhibit ODC can inhibit tumor formation. Using fasting human volunteers, we report that human epidermal and dermal ODC are consistently induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in a manner similar to that seen in mouse skin. There is a marked intersubject variation in TPA-induced epidermal ODC activity levels. Orally administered compounds significantly inhibited TPA-caused human epidermal ODC induction. These data may be useful in the furthest development of drugs, doses, and dose schedules for use in human cancer chemoprevention studies.
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U2 - 10.1200/JCO.1985.3.6.751
DO - 10.1200/JCO.1985.3.6.751
M3 - Article
C2 - 3859584
AN - SCOPUS:0021867577
SN - 0732-183X
VL - 3
SP - 751
EP - 757
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 6
ER -