Inhibition of phorbol ester-induced human epidermal ornithine decarboxylase activity by oral compounds: A possible role in human chemoprevention studies

C. L. Loprinzi, A. K. Verma, R. K. Boutwell, P. P. Carbone

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Extensive animal data have suggested that, in some systems, the induction of ornithine decarboxylase (ODC) is an essential, although not sufficient, aspect of tumor promotion and that compounds that inhibit ODC can inhibit tumor formation. Using fasting human volunteers, we report that human epidermal and dermal ODC are consistently induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in a manner similar to that seen in mouse skin. There is a marked intersubject variation in TPA-induced epidermal ODC activity levels. Orally administered compounds significantly inhibited TPA-caused human epidermal ODC induction. These data may be useful in the furthest development of drugs, doses, and dose schedules for use in human cancer chemoprevention studies.

Original languageEnglish (US)
Pages (from-to)751-757
Number of pages7
JournalJournal of Clinical Oncology
Volume3
Issue number6
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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