Inhibition of phorbol ester-induced human epidermal ornithine decarboxylase activity by oral compounds

A possible role in human chemoprevention studies

Charles Lawrence Loprinzi, A. K. Verma, R. K. Boutwell, P. P. Carbone

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Extensive animal data have suggested that, in some systems, the induction of ornithine decarboxylase (ODC) is an essential, although not sufficient, aspect of tumor promotion and that compounds that inhibit ODC can inhibit tumor formation. Using fasting human volunteers, we report that human epidermal and dermal ODC are consistently induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in a manner similar to that seen in mouse skin. There is a marked intersubject variation in TPA-induced epidermal ODC activity levels. Orally administered compounds significantly inhibited TPA-caused human epidermal ODC induction. These data may be useful in the furthest development of drugs, doses, and dose schedules for use in human cancer chemoprevention studies.

Original languageEnglish (US)
Pages (from-to)751-757
Number of pages7
JournalJournal of Clinical Oncology
Volume3
Issue number6
StatePublished - 1985
Externally publishedYes

Fingerprint

Ornithine Decarboxylase
Chemoprevention
Phorbol Esters
Tetradecanoylphorbol Acetate
Neoplasms
Skin
Carcinogens
Volunteers
Fasting
Appointments and Schedules
Inhibition (Psychology)
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Inhibition of phorbol ester-induced human epidermal ornithine decarboxylase activity by oral compounds : A possible role in human chemoprevention studies. / Loprinzi, Charles Lawrence; Verma, A. K.; Boutwell, R. K.; Carbone, P. P.

In: Journal of Clinical Oncology, Vol. 3, No. 6, 1985, p. 751-757.

Research output: Contribution to journalArticle

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