Inhibition of ornithine decarboxylase activity by small doses of α-difluoromethylornithine

C. L. Loprinzi; A. K. Verma

doi:10.1016/0304-3835(85)90042-4

Inhibition of ornithine decarboxylase activity by small doses of α-difluoromethylornithine

C. L. Loprinzi, A. K. Verma

Medical Oncology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The induction of ornithine decarboxylase (ODC) appears to be an important aspect of carcinogenesis. Agents which inhibit ODC have been shown to preclude cancer formation in many organ systems. We studied the dose and dose schedule of α-difluoromethylornithine (DFMO), a suicide inhibitor of ODC, needed to effectively inhibit ODC activity in mice. Our data demonstrate that doses many-fold lower than comparable maximal tolerated doses in humans can inhibit ODC activity in mice. In addition, a simplified, once daily dosage of DFMO appears adequate.

Original language	English (US)
Pages (from-to)	327-333
Number of pages	7
Journal	Cancer Letters
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(85)90042-4
State	Published - Sep 30 1985

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(85)90042-4

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title = "Inhibition of ornithine decarboxylase activity by small doses of α-difluoromethylornithine",

abstract = "The induction of ornithine decarboxylase (ODC) appears to be an important aspect of carcinogenesis. Agents which inhibit ODC have been shown to preclude cancer formation in many organ systems. We studied the dose and dose schedule of α-difluoromethylornithine (DFMO), a suicide inhibitor of ODC, needed to effectively inhibit ODC activity in mice. Our data demonstrate that doses many-fold lower than comparable maximal tolerated doses in humans can inhibit ODC activity in mice. In addition, a simplified, once daily dosage of DFMO appears adequate.",

author = "Loprinzi, {C. L.} and Verma, {A. K.}",

note = "Funding Information: The authors thank Lisa Duvick for technical assistance,M ary Pankratz and Suzi Pertzborn for manuscript preparation, and Dr. R.K. Boutwell for useful discussion and encouragement.T his work was supported in part by the University of Wisconsin Food Research Institute, the American Cancer Society, and PHS Grants 1 K08 CA 00989 and CA 36323 awarded by the National Cancer Institute, DHHS.",

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doi = "10.1016/0304-3835(85)90042-4",

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T1 - Inhibition of ornithine decarboxylase activity by small doses of α-difluoromethylornithine

AU - Loprinzi, C. L.

AU - Verma, A. K.

N1 - Funding Information: The authors thank Lisa Duvick for technical assistance,M ary Pankratz and Suzi Pertzborn for manuscript preparation, and Dr. R.K. Boutwell for useful discussion and encouragement.T his work was supported in part by the University of Wisconsin Food Research Institute, the American Cancer Society, and PHS Grants 1 K08 CA 00989 and CA 36323 awarded by the National Cancer Institute, DHHS.

PY - 1985/9/30

Y1 - 1985/9/30

N2 - The induction of ornithine decarboxylase (ODC) appears to be an important aspect of carcinogenesis. Agents which inhibit ODC have been shown to preclude cancer formation in many organ systems. We studied the dose and dose schedule of α-difluoromethylornithine (DFMO), a suicide inhibitor of ODC, needed to effectively inhibit ODC activity in mice. Our data demonstrate that doses many-fold lower than comparable maximal tolerated doses in humans can inhibit ODC activity in mice. In addition, a simplified, once daily dosage of DFMO appears adequate.

AB - The induction of ornithine decarboxylase (ODC) appears to be an important aspect of carcinogenesis. Agents which inhibit ODC have been shown to preclude cancer formation in many organ systems. We studied the dose and dose schedule of α-difluoromethylornithine (DFMO), a suicide inhibitor of ODC, needed to effectively inhibit ODC activity in mice. Our data demonstrate that doses many-fold lower than comparable maximal tolerated doses in humans can inhibit ODC activity in mice. In addition, a simplified, once daily dosage of DFMO appears adequate.

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Inhibition of ornithine decarboxylase activity by small doses of α-difluoromethylornithine

Abstract

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