Inhibition of ornithine decarboxylase activity by small doses of α-difluoromethylornithine

C. L. Loprinzi, A. K. Verma

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The induction of ornithine decarboxylase (ODC) appears to be an important aspect of carcinogenesis. Agents which inhibit ODC have been shown to preclude cancer formation in many organ systems. We studied the dose and dose schedule of α-difluoromethylornithine (DFMO), a suicide inhibitor of ODC, needed to effectively inhibit ODC activity in mice. Our data demonstrate that doses many-fold lower than comparable maximal tolerated doses in humans can inhibit ODC activity in mice. In addition, a simplified, once daily dosage of DFMO appears adequate.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalCancer Letters
Volume28
Issue number3
DOIs
StatePublished - Sep 30 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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