Inhibition of HIV-1 replication by simian restriction factors, TRIM5α and APOBEC3G

R. Sakuma, J. A. Noser, S. Ohmine, Y. Ikeda

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Old World monkey TRIM5α targets incoming human immunodeficiency virus type 1 (HIV-1) viral capsid, whereas the apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like (APOBEC)3 family hypermutate/degrade viral sequences. Here, we show the potentials of simian TRIM5α and APOBEC3G as therapeutic sequences for AIDS gene therapy. Both rhesus and African green monkey (agm) TRIM5α efficiently restrict HIV-1 vectors with divergent Gag from different HIV-1 subtypes. Human T cells genetically engineered to express agm-TRIM5α block or delay HIV-1 replication. Although agm-APOBEC3G expression alone only transiently suppresses HIV-1 replication, co-expression of agm-APOBEC3G and agm-TRIM5α successfully block the virus replication for more than 5 weeks.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalGene Therapy
Volume14
Issue number2
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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