Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs

Charles Lawrence Loprinzi, D. B. Wender, M. H. Veeder, J. R. O'Fallon, N. L. Vaught, A. M. Dose, C. Ghosh, J. Bartel, J. M. Leitch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background. This clinical trial was developed to determine whether ocular ice pack therapy would decrease 5-fluorouracil (5-FU)-induced ocular toxicity. Methods. Sixty-two patients who suffered from 5-FU-induced ocular toxicity, and were scheduled to receive another cycle of the chemotherapy that caused the ocular toxicity, were entered in this clinical trial. A randomized, crossover design was used, with patients documenting their ocular toxicity by the use of daily diaries. Results. The results from the first cycle of treatment suggested that ocular ice pack therapy decreased 5-FU- induced ocular toxicity (P = 0.056). The 38 evaluable patients in the crossover analyses demonstrated decreased ocular toxicity with ocular ice pack therapy (p=.001). The ocular ice pack therapy was well tolerated by most of the study participants. Conclusion. Ocular ice pack therapy appears to lessen 5-FU-induced ocular toxicity to a clinically moderate degree. Better methods for decreasing 5-FU-induced ocular toxicity are necessary.

Original languageEnglish (US)
Pages (from-to)945-948
Number of pages4
JournalCancer
Volume74
Issue number3 SUPPL.
DOIs
StatePublished - 1994

Fingerprint

Ice
Fluorouracil
Therapeutics
Clinical Trials
Cross-Over Studies

Keywords

  • 5-fluorouracil-induced conjunctivitis
  • 5-fluorouracil-induced ocular toxicity
  • ocular ice packs

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Loprinzi, C. L., Wender, D. B., Veeder, M. H., O'Fallon, J. R., Vaught, N. L., Dose, A. M., ... Leitch, J. M. (1994). Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs. Cancer, 74(3 SUPPL.), 945-948. https://doi.org/10.1002/1097-0142(19940801)74:3<945::AID-CNCR2820740324>3.0.CO;2-C

Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs. / Loprinzi, Charles Lawrence; Wender, D. B.; Veeder, M. H.; O'Fallon, J. R.; Vaught, N. L.; Dose, A. M.; Ghosh, C.; Bartel, J.; Leitch, J. M.

In: Cancer, Vol. 74, No. 3 SUPPL., 1994, p. 945-948.

Research output: Contribution to journalArticle

Loprinzi, CL, Wender, DB, Veeder, MH, O'Fallon, JR, Vaught, NL, Dose, AM, Ghosh, C, Bartel, J & Leitch, JM 1994, 'Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs', Cancer, vol. 74, no. 3 SUPPL., pp. 945-948. https://doi.org/10.1002/1097-0142(19940801)74:3<945::AID-CNCR2820740324>3.0.CO;2-C
Loprinzi, Charles Lawrence ; Wender, D. B. ; Veeder, M. H. ; O'Fallon, J. R. ; Vaught, N. L. ; Dose, A. M. ; Ghosh, C. ; Bartel, J. ; Leitch, J. M. / Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs. In: Cancer. 1994 ; Vol. 74, No. 3 SUPPL. pp. 945-948.
@article{c55ffc69217443dd9d3c1b3c7317479e,
title = "Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs",
abstract = "Background. This clinical trial was developed to determine whether ocular ice pack therapy would decrease 5-fluorouracil (5-FU)-induced ocular toxicity. Methods. Sixty-two patients who suffered from 5-FU-induced ocular toxicity, and were scheduled to receive another cycle of the chemotherapy that caused the ocular toxicity, were entered in this clinical trial. A randomized, crossover design was used, with patients documenting their ocular toxicity by the use of daily diaries. Results. The results from the first cycle of treatment suggested that ocular ice pack therapy decreased 5-FU- induced ocular toxicity (P = 0.056). The 38 evaluable patients in the crossover analyses demonstrated decreased ocular toxicity with ocular ice pack therapy (p=.001). The ocular ice pack therapy was well tolerated by most of the study participants. Conclusion. Ocular ice pack therapy appears to lessen 5-FU-induced ocular toxicity to a clinically moderate degree. Better methods for decreasing 5-FU-induced ocular toxicity are necessary.",
keywords = "5-fluorouracil-induced conjunctivitis, 5-fluorouracil-induced ocular toxicity, ocular ice packs",
author = "Loprinzi, {Charles Lawrence} and Wender, {D. B.} and Veeder, {M. H.} and O'Fallon, {J. R.} and Vaught, {N. L.} and Dose, {A. M.} and C. Ghosh and J. Bartel and Leitch, {J. M.}",
year = "1994",
doi = "10.1002/1097-0142(19940801)74:3<945::AID-CNCR2820740324>3.0.CO;2-C",
language = "English (US)",
volume = "74",
pages = "945--948",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "3 SUPPL.",

}

TY - JOUR

T1 - Inhibition of 5-fluorouracil-induced ocular irritation by ocular ice packs

AU - Loprinzi, Charles Lawrence

AU - Wender, D. B.

AU - Veeder, M. H.

AU - O'Fallon, J. R.

AU - Vaught, N. L.

AU - Dose, A. M.

AU - Ghosh, C.

AU - Bartel, J.

AU - Leitch, J. M.

PY - 1994

Y1 - 1994

N2 - Background. This clinical trial was developed to determine whether ocular ice pack therapy would decrease 5-fluorouracil (5-FU)-induced ocular toxicity. Methods. Sixty-two patients who suffered from 5-FU-induced ocular toxicity, and were scheduled to receive another cycle of the chemotherapy that caused the ocular toxicity, were entered in this clinical trial. A randomized, crossover design was used, with patients documenting their ocular toxicity by the use of daily diaries. Results. The results from the first cycle of treatment suggested that ocular ice pack therapy decreased 5-FU- induced ocular toxicity (P = 0.056). The 38 evaluable patients in the crossover analyses demonstrated decreased ocular toxicity with ocular ice pack therapy (p=.001). The ocular ice pack therapy was well tolerated by most of the study participants. Conclusion. Ocular ice pack therapy appears to lessen 5-FU-induced ocular toxicity to a clinically moderate degree. Better methods for decreasing 5-FU-induced ocular toxicity are necessary.

AB - Background. This clinical trial was developed to determine whether ocular ice pack therapy would decrease 5-fluorouracil (5-FU)-induced ocular toxicity. Methods. Sixty-two patients who suffered from 5-FU-induced ocular toxicity, and were scheduled to receive another cycle of the chemotherapy that caused the ocular toxicity, were entered in this clinical trial. A randomized, crossover design was used, with patients documenting their ocular toxicity by the use of daily diaries. Results. The results from the first cycle of treatment suggested that ocular ice pack therapy decreased 5-FU- induced ocular toxicity (P = 0.056). The 38 evaluable patients in the crossover analyses demonstrated decreased ocular toxicity with ocular ice pack therapy (p=.001). The ocular ice pack therapy was well tolerated by most of the study participants. Conclusion. Ocular ice pack therapy appears to lessen 5-FU-induced ocular toxicity to a clinically moderate degree. Better methods for decreasing 5-FU-induced ocular toxicity are necessary.

KW - 5-fluorouracil-induced conjunctivitis

KW - 5-fluorouracil-induced ocular toxicity

KW - ocular ice packs

UR - http://www.scopus.com/inward/record.url?scp=0028136508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028136508&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19940801)74:3<945::AID-CNCR2820740324>3.0.CO;2-C

DO - 10.1002/1097-0142(19940801)74:3<945::AID-CNCR2820740324>3.0.CO;2-C

M3 - Article

C2 - 8039123

AN - SCOPUS:0028136508

VL - 74

SP - 945

EP - 948

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 3 SUPPL.

ER -