Inhibin A is a sensitive and specific marker for testicular sex cord- stromal tumors

Kenneth A. Iczkowski, David G. Bostwick, Patrick C. Roche, John C. Cheville

Research output: Contribution to journalArticle

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Abstract

We compared the expression of inhibin A, chromogranin, synaptophysin, S- 100 protein, cytokeratins AE1/AE3, 7, and 20, and estrogen and progesterone receptors in testicular sex cord-stromal tumors: 11 Sertoli cell tumors, 3 Sertoli cell adenomas (nodules), 26 benign Leydig cell tumors, 7 malignant Leydig cell tumors (defined clinically by metastatic behavior), and a variety of germ cell tumors. Inhibin was the most sensitive marker, expressed in 91% of the Sertoli cell minors and 100% of the Sertoli cell adenomas and Leydig cell tumors. The nonneoplastic Sertoli and Leydig cells invariably stained for inhibin. Conversely, no germ cell tumors were immunoreactive. One testicular tumor of the adrenogenital syndrome was immunoreactive. Neuroendocrine marker immunoreactivity was variable. Chromogranin was expressed in the nonneoplastic Sertoli and Leydig cells, 82% of the Sertoli cell tumors, 92% of the benign Leydig cell tumors, and 43% of the malignant Leydig cell tumors. Synaptophysin was expressed in the nonneoplastic Sertoli and Leydig cells, 45% of the Sertoli cell tumors, and 70% of the Leydig cell tumors, in approximately similar proportions between the benign and malignant Leydig cell tumors. S-100 protein was expressed in 64% of the Sertoli cell tumors, 8% of the benign Leydig cell tumors, and none of the malignant Leydig cell tumors. Cytokeratins AE1/AE3 were expressed in 64% of the Sertoli cell tumors and 42% of the Leydig cell tumors, with similar proportions in the benign and malignant cases. Estrogen and progesterone receptor expression were identified in 24 and 39% of benign and malignant Leydig cell tumors, respectively. We conclude that inhibin is a characteristic marker for Sertoli and Leydig cells and that it serves to differentiate testicular sex cord- stromal tumors from germ cell tumors.

Original languageEnglish (US)
Pages (from-to)774-779
Number of pages6
JournalModern Pathology
Volume11
Issue number8
StatePublished - Aug 1998

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Sex Cord-Gonadal Stromal Tumors
Leydig Cell Tumor
Testicular Neoplasms
Sertoli Cells
Sertoli Cell Tumor
Leydig Cells
Inhibins
Germ Cell and Embryonal Neoplasms
Chromogranins
Synaptophysin
S100 Proteins
Progesterone Receptors
Keratins
Estrogen Receptors
Adenoma
inhibin A
Adrenogenital Syndrome
Minors

Keywords

  • Germ cell tumor
  • Immunohistochemistry
  • Inhibin
  • Leydig cell
  • Sertoli cell
  • Sex cord-stromal tumor
  • Testis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Iczkowski, K. A., Bostwick, D. G., Roche, P. C., & Cheville, J. C. (1998). Inhibin A is a sensitive and specific marker for testicular sex cord- stromal tumors. Modern Pathology, 11(8), 774-779.

Inhibin A is a sensitive and specific marker for testicular sex cord- stromal tumors. / Iczkowski, Kenneth A.; Bostwick, David G.; Roche, Patrick C.; Cheville, John C.

In: Modern Pathology, Vol. 11, No. 8, 08.1998, p. 774-779.

Research output: Contribution to journalArticle

Iczkowski, KA, Bostwick, DG, Roche, PC & Cheville, JC 1998, 'Inhibin A is a sensitive and specific marker for testicular sex cord- stromal tumors', Modern Pathology, vol. 11, no. 8, pp. 774-779.
Iczkowski KA, Bostwick DG, Roche PC, Cheville JC. Inhibin A is a sensitive and specific marker for testicular sex cord- stromal tumors. Modern Pathology. 1998 Aug;11(8):774-779.
Iczkowski, Kenneth A. ; Bostwick, David G. ; Roche, Patrick C. ; Cheville, John C. / Inhibin A is a sensitive and specific marker for testicular sex cord- stromal tumors. In: Modern Pathology. 1998 ; Vol. 11, No. 8. pp. 774-779.
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N2 - We compared the expression of inhibin A, chromogranin, synaptophysin, S- 100 protein, cytokeratins AE1/AE3, 7, and 20, and estrogen and progesterone receptors in testicular sex cord-stromal tumors: 11 Sertoli cell tumors, 3 Sertoli cell adenomas (nodules), 26 benign Leydig cell tumors, 7 malignant Leydig cell tumors (defined clinically by metastatic behavior), and a variety of germ cell tumors. Inhibin was the most sensitive marker, expressed in 91% of the Sertoli cell minors and 100% of the Sertoli cell adenomas and Leydig cell tumors. The nonneoplastic Sertoli and Leydig cells invariably stained for inhibin. Conversely, no germ cell tumors were immunoreactive. One testicular tumor of the adrenogenital syndrome was immunoreactive. Neuroendocrine marker immunoreactivity was variable. Chromogranin was expressed in the nonneoplastic Sertoli and Leydig cells, 82% of the Sertoli cell tumors, 92% of the benign Leydig cell tumors, and 43% of the malignant Leydig cell tumors. Synaptophysin was expressed in the nonneoplastic Sertoli and Leydig cells, 45% of the Sertoli cell tumors, and 70% of the Leydig cell tumors, in approximately similar proportions between the benign and malignant Leydig cell tumors. S-100 protein was expressed in 64% of the Sertoli cell tumors, 8% of the benign Leydig cell tumors, and none of the malignant Leydig cell tumors. Cytokeratins AE1/AE3 were expressed in 64% of the Sertoli cell tumors and 42% of the Leydig cell tumors, with similar proportions in the benign and malignant cases. Estrogen and progesterone receptor expression were identified in 24 and 39% of benign and malignant Leydig cell tumors, respectively. We conclude that inhibin is a characteristic marker for Sertoli and Leydig cells and that it serves to differentiate testicular sex cord- stromal tumors from germ cell tumors.

AB - We compared the expression of inhibin A, chromogranin, synaptophysin, S- 100 protein, cytokeratins AE1/AE3, 7, and 20, and estrogen and progesterone receptors in testicular sex cord-stromal tumors: 11 Sertoli cell tumors, 3 Sertoli cell adenomas (nodules), 26 benign Leydig cell tumors, 7 malignant Leydig cell tumors (defined clinically by metastatic behavior), and a variety of germ cell tumors. Inhibin was the most sensitive marker, expressed in 91% of the Sertoli cell minors and 100% of the Sertoli cell adenomas and Leydig cell tumors. The nonneoplastic Sertoli and Leydig cells invariably stained for inhibin. Conversely, no germ cell tumors were immunoreactive. One testicular tumor of the adrenogenital syndrome was immunoreactive. Neuroendocrine marker immunoreactivity was variable. Chromogranin was expressed in the nonneoplastic Sertoli and Leydig cells, 82% of the Sertoli cell tumors, 92% of the benign Leydig cell tumors, and 43% of the malignant Leydig cell tumors. Synaptophysin was expressed in the nonneoplastic Sertoli and Leydig cells, 45% of the Sertoli cell tumors, and 70% of the Leydig cell tumors, in approximately similar proportions between the benign and malignant Leydig cell tumors. S-100 protein was expressed in 64% of the Sertoli cell tumors, 8% of the benign Leydig cell tumors, and none of the malignant Leydig cell tumors. Cytokeratins AE1/AE3 were expressed in 64% of the Sertoli cell tumors and 42% of the Leydig cell tumors, with similar proportions in the benign and malignant cases. Estrogen and progesterone receptor expression were identified in 24 and 39% of benign and malignant Leydig cell tumors, respectively. We conclude that inhibin is a characteristic marker for Sertoli and Leydig cells and that it serves to differentiate testicular sex cord- stromal tumors from germ cell tumors.

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