Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps

Ellen L Goode, John D. Potter, William R. Bamlet, David N. Rider, Jeannette Bigler

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Exposures such as cigarette smoke and meat contain a variety of procarcinogens, which are thought to play a role in elevation of risk for colorectal polyps and/or cancer. These procarcinogens (including heterocyclic amines and polycyclic aromatic hydrocarbons) are metabolized by a variety of polymorphic enzymes including N-acetyltransferases, sulfotransferases, cytochrome P450 enzymes and epoxide hydrolase. We hypothesized that genetic variation in the encoding genes NAT1, NAT2, SULT1A1, SULT1A2, CYP1A1 or EPHX1 is associated with risk of colorectal polyps and interacts with cigarette use or meat intake to modify risk of colorectal polyps. We examined the role of these genes in a clinic-based study of 651 Caucasian cases with hyperplastic polyps, adenomatous polyps or both types of polyps and 556 polyp-free controls. We found evidence for interaction between NAT acetylator status and SULT1A1 genotype in risk of hyperplastic polyps: individuals with SULT1A1 638AA genotype and NAT1 and NAT2 intermediate/ fast phenotypes had 3.5-fold increased risk (95% CI 1.2-10.3) compared with individuals with SULT1A1 638GG genotype and NAT1 and NAT2 slow phenotypes. Data were also consistent with interactions between smoking and variation in SULT1A1, CYP1A1 and EPHX1 and between meat intake and variation in CYP1A1 and EPHX1. No interactions were statistically significant. Although results should be interpreted with caution considering sample size and the number of hypotheses examined, our study suggests future avenues of investigation in larger investigations of genetic and lifestyle factors in the pathway to colorectal cancer.

Original languageEnglish (US)
Pages (from-to)328-341
Number of pages14
JournalCarcinogenesis
Volume28
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Polyps
Carcinogens
Enzymes
Cytochrome P-450 CYP1A1
Meat
Genotype
Tobacco Products
Cytochrome P-450 Enzyme System
Phenotype
Adenomatous Polyps
Epoxide Hydrolases
Sulfotransferases
Acetyltransferases
Polycyclic Aromatic Hydrocarbons
Smoke
Sample Size
Genes
Amines
Life Style
Colorectal Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. / Goode, Ellen L; Potter, John D.; Bamlet, William R.; Rider, David N.; Bigler, Jeannette.

In: Carcinogenesis, Vol. 28, No. 2, 02.2007, p. 328-341.

Research output: Contribution to journalArticle

Goode, Ellen L ; Potter, John D. ; Bamlet, William R. ; Rider, David N. ; Bigler, Jeannette. / Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. In: Carcinogenesis. 2007 ; Vol. 28, No. 2. pp. 328-341.
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