Inherited neuroaxonal dystrophy in C6 deficient rabbits

C. Giannini, S. Monaco, M. Kirschfink, K. O. Rother, H. Lorbacher De Ruiz, E. Nardelli, B. Bonetti, A. Salviati, G. P. Zanette, N. Rizzuto

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We report the occurrence of a progressive neurological syndrome clinically characterized by subacute motor neuropathy in offspring of C6 deficient rabbits. On the basis of the pedigree analysis, the disease appears to be genetically transmitted, most probably with an autosomal recessive mode of inheritance. Pathological studies of affected animals revealed: 1) severe axonal degeneration in the sciatic nerve system involving mainly motor fibers; 2) occasional peripheral axonal enlargement closely associated with axonal degeneration; 3) presence of structured abnormal material in normal-size myelinated fibers of central nervous system (CNS) and peripheral nervous system (PNS); and 4) widespread occurrence of dystrophic axons and axonal spheroids in the gray matter of CNS. By ultrastructural examination, dystrophic axons are filled with tubulo-vesicular material, stalks of parallel membranes and dense bodies similar to what is described in human neuroaxonal dystrophies (NAD). The disease manifested by C6 deficient rabbits may represent an animal model of primary human NAD.

Original languageEnglish (US)
Pages (from-to)514-522
Number of pages9
JournalJournal of Neuropathology and Experimental Neurology
Volume51
Issue number5
DOIs
StatePublished - Sep 1992

Keywords

  • Axonal degeneration
  • Axonal spheroid
  • C6 deficient rabbits
  • Dystrophic axon
  • Inherited neuroaxonal dystrophy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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